Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 125657..126314 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP082149 | ||
| Organism | Enterobacter cloacae complex sp. strain ECL42 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | K6966_RS26135 | Protein ID | WP_000270043.1 |
| Coordinates | 125964..126314 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K6966_RS26130 | Protein ID | WP_000124640.1 |
| Coordinates | 125657..125959 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6966_RS26085 (K6966_26085) | 121282..121710 | + | 429 | WP_072713905.1 | hypothetical protein | - |
| K6966_RS26090 (K6966_26090) | 121767..122126 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| K6966_RS26095 (K6966_26095) | 122126..122572 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| K6966_RS26100 (K6966_26100) | 122569..123087 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| K6966_RS26105 (K6966_26105) | 123087..123317 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| K6966_RS26110 (K6966_26110) | 123304..124161 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| K6966_RS26115 (K6966_26115) | 124392..124919 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| K6966_RS26120 (K6966_26120) | 124977..125249 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| K6966_RS26125 (K6966_26125) | 125337..125630 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| K6966_RS26130 (K6966_26130) | 125657..125959 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| K6966_RS26135 (K6966_26135) | 125964..126314 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6966_RS26140 (K6966_26140) | 126477..127025 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| K6966_RS26145 (K6966_26145) | 127366..127560 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| K6966_RS26150 (K6966_26150) | 127571..127942 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| K6966_RS26155 (K6966_26155) | 127935..128405 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| K6966_RS26160 (K6966_26160) | 128420..128755 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| K6966_RS26165 (K6966_26165) | 128852..129340 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| K6966_RS26170 (K6966_26170) | 129343..129840 | + | 498 | WP_000062185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaSFO-1 / blaIMP-4 / catB3 / qacE / sul1 / aac(6')-Ib-cr / blaOXA-1 / ARR-3 / armA / msr(E) / mph(E) | - | 1..217402 | 217402 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T214228 WP_000270043.1 NZ_CP082149:c126314-125964 [Enterobacter cloacae complex sp.]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T214228 NZ_CP110016:c1733274-1732987 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT214228 WP_000124640.1 NZ_CP082149:c125959-125657 [Enterobacter cloacae complex sp.]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT214228 NZ_CP110016:c1733513-1733274 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|