Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1211592..1212241 Replicon chromosome
Accession NZ_CP082147
Organism Enterobacter cloacae complex sp. strain ECL42

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K6966_RS05745 Protein ID WP_222834795.1
Coordinates 1211879..1212241 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag K6966_RS05740 Protein ID WP_014882863.1
Coordinates 1211592..1211891 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6966_RS05730 (K6966_05730) 1208017..1209990 + 1974 WP_078310105.1 PhoX family phosphatase -
K6966_RS05735 (K6966_05735) 1210093..1211481 + 1389 WP_058690612.1 phenylalanine transporter -
K6966_RS05740 (K6966_05740) 1211592..1211891 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
K6966_RS05745 (K6966_05745) 1211879..1212241 - 363 WP_222834795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6966_RS05750 (K6966_05750) 1212447..1213682 + 1236 WP_023332295.1 MFS transporter -
K6966_RS05755 (K6966_05755) 1213698..1214723 + 1026 WP_032637265.1 sugar phosphate isomerase/epimerase -
K6966_RS05760 (K6966_05760) 1214716..1215858 + 1143 WP_058690611.1 Gfo/Idh/MocA family oxidoreductase -
K6966_RS05765 (K6966_05765) 1215934..1216956 + 1023 WP_058690610.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13939.83 Da        Isoelectric Point: 5.6482

>T214214 WP_222834795.1 NZ_CP082147:c1212241-1211879 [Enterobacter cloacae complex sp.]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVNASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T214214 NZ_CP110015:c3797200-3797093 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT214214 WP_014882863.1 NZ_CP082147:c1211891-1211592 [Enterobacter cloacae complex sp.]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT214214 NZ_CP110015:3797248-3797314 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References