Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 754857..755550 Replicon chromosome
Accession NZ_CP082129
Organism Escherichia coli strain NDM_11.16372

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K5P77_RS03655 Protein ID WP_000415584.1
Coordinates 754857..755153 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K5P77_RS03660 Protein ID WP_000650107.1
Coordinates 755155..755550 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5P77_RS03620 (749945) 749945..750259 - 315 WP_000958598.1 putative quinol monooxygenase -
K5P77_RS03625 (750290) 750290..750871 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K5P77_RS03630 (751190) 751190..751522 + 333 WP_000917685.1 DUF2645 family protein -
K5P77_RS03635 (751568) 751568..752917 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K5P77_RS03640 (752914) 752914..753573 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K5P77_RS03645 (753725) 753725..754117 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K5P77_RS03650 (754170) 754170..754652 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K5P77_RS03655 (754857) 754857..755153 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K5P77_RS03660 (755155) 755155..755550 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K5P77_RS03665 (755683) 755683..757290 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K5P77_RS03670 (757428) 757428..759686 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T214177 WP_000415584.1 NZ_CP082129:754857-755153 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T214177 NZ_CP110014:c2011784-2011681 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT214177 WP_000650107.1 NZ_CP082129:755155-755550 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT214177 NZ_CP110014:2011643-2011914 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References