Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741184..741959 Replicon chromosome
Accession NZ_CP082032
Organism Klebsiella pneumoniae strain KP18-2138

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag K6163_RS03700 Protein ID WP_004150910.1
Coordinates 741474..741959 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag K6163_RS03695 Protein ID WP_004150912.1
Coordinates 741184..741477 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6163_RS03675 736392..736994 - 603 WP_062954968.1 short chain dehydrogenase -
K6163_RS03680 737092..738003 + 912 WP_004188550.1 LysR family transcriptional regulator -
K6163_RS03685 738004..739152 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
K6163_RS03690 739163..740539 - 1377 WP_004217775.1 cystathionine beta-synthase -
K6163_RS03695 741184..741477 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
K6163_RS03700 741474..741959 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
K6163_RS03705 742663..743256 + 594 WP_004188553.1 hypothetical protein -
K6163_RS03710 743353..743569 + 217 Protein_730 transposase -
K6163_RS03715 744175..745047 + 873 WP_004188557.1 ParA family protein -
K6163_RS03720 745047..745430 + 384 WP_004150906.1 hypothetical protein -
K6163_RS03725 745423..746790 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743353..743505 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T214033 WP_004150910.1 NZ_CP082032:741474-741959 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T214033 NZ_CP109942:c891687-890920 [Streptococcus suis]
ATGAGGTTGGAAGAATTCAGTGAGGCTGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGGTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCCCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTTGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT214033 WP_004150912.1 NZ_CP082032:741184-741477 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT214033 NZ_CP109942:c892163-891687 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References