Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 347052..347638 Replicon chromosome
Accession NZ_CP082029
Organism Klebsiella pneumoniae strain KP18-2113

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag K6164_RS01690 Protein ID WP_002920800.1
Coordinates 347270..347638 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K6164_RS01685 Protein ID WP_004174006.1
Coordinates 347052..347273 (+) Length 74 a.a.

Genomic Context


K6164_RS01665K6164_RS01670K6164_RS01675K6164_RS01680K6164_RS01685K6164_RS01690K6164_RS01695K6164_RS01700K6164_RS01705K6164_RS01710
Location: 343209..344135 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 344132..345409 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 345406..346173 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 346175..346888 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 347052..347273 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 347270..347638 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 347911..349227 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Location: 349334..350221 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 350218..351063 (846 bp)
Type: Others
Protein ID: WP_004181473.1
Location: 351065..352135 (1071 bp)
Type: Others
Protein ID: WP_004150074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6164_RS01665 (343209)343209..344135+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
K6164_RS01670 (344132)344132..345409+1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
K6164_RS01675 (345406)345406..346173+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
K6164_RS01680 (346175)346175..346888+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
K6164_RS01685 (347052)347052..347273+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6164_RS01690 (347270)347270..347638+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
K6164_RS01695 (347911)347911..349227+1317WP_004174008.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
K6164_RS01700 (349334)349334..350221+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
K6164_RS01705 (350218)350218..351063+846WP_004181473.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
K6164_RS01710 (351065)351065..352135+1071WP_004150074.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--344132..3528728740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T214005 WP_002920800.1 NZ_CP082029:347270-347638 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T214005 NZ_CP109933:2410211-2410477 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT214005 WP_004174006.1 NZ_CP082029:347052-347273 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT214005 NZ_CP109933:2409954-2410211 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References