Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 134741..134994 | Replicon | plasmid pKP18-2050-KPC2 |
| Accession | NZ_CP082020 | ||
| Organism | Klebsiella pneumoniae strain KP18-2050 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | K6159_RS28720 | Protein ID | WP_001312851.1 |
| Coordinates | 134845..134994 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 134741..134800 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6159_RS28680 (130401) | 130401..130466 | - | 66 | Protein_174 | helix-turn-helix domain-containing protein | - |
| K6159_RS28685 (130519) | 130519..131223 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| K6159_RS28690 (131248) | 131248..131448 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| K6159_RS28695 (131468) | 131468..132214 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| K6159_RS28700 (132269) | 132269..132829 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| K6159_RS28705 (132961) | 132961..133161 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| K6159_RS28710 (133547) | 133547..134146 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| K6159_RS28715 (134208) | 134208..134540 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (134741) | 134741..134800 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (134741) | 134741..134800 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (134741) | 134741..134800 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (134741) | 134741..134800 | - | 60 | NuclAT_1 | - | Antitoxin |
| K6159_RS28720 (134845) | 134845..134994 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| K6159_RS28725 (135278) | 135278..135526 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| K6159_RS30300 (135641) | 135641..135825 | + | 185 | Protein_184 | protein CopA/IncA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 | - | 1..135837 | 135837 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T213966 WP_001312851.1 NZ_CP082020:134845-134994 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T213966 NZ_CP109929:1925799-1926050 [Escherichia coli O6:K2:H1]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Antitoxin
Download Length: 60 bp
>AT213966 NZ_CP082020:c134800-134741 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
