Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 89948..90374 | Replicon | plasmid pKP18-1-KPC2 |
Accession | NZ_CP082003 | ||
Organism | Klebsiella pneumoniae strain KP18-1 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | K6149_RS28470 | Protein ID | WP_001372321.1 |
Coordinates | 89948..90073 (-) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 90150..90374 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6149_RS28435 (85003) | 85003..85230 | - | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
K6149_RS28440 (85324) | 85324..86010 | - | 687 | WP_015059009.1 | PAS domain-containing protein | - |
K6149_RS28445 (86201) | 86201..86584 | - | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
K6149_RS28450 (86861) | 86861..87508 | + | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
K6149_RS28455 (87805) | 87805..88626 | - | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
K6149_RS28460 (88737) | 88737..89033 | - | 297 | WP_001272251.1 | hypothetical protein | - |
K6149_RS28465 (89333) | 89333..89629 | + | 297 | Protein_115 | hypothetical protein | - |
K6149_RS28470 (89948) | 89948..90073 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
K6149_RS29125 (90015) | 90015..90164 | - | 150 | Protein_117 | plasmid maintenance protein Mok | - |
- (90150) | 90150..90374 | - | 225 | NuclAT_0 | - | Antitoxin |
- (90150) | 90150..90374 | - | 225 | NuclAT_0 | - | Antitoxin |
- (90150) | 90150..90374 | - | 225 | NuclAT_0 | - | Antitoxin |
- (90150) | 90150..90374 | - | 225 | NuclAT_0 | - | Antitoxin |
K6149_RS28475 (90386) | 90386..91105 | - | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
K6149_RS28480 (91102) | 91102..91536 | - | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
K6149_RS28485 (91605) | 91605..93628 | - | 2024 | Protein_120 | ParB/RepB/Spo0J family partition protein | - |
K6149_RS28490 (93689) | 93689..93922 | - | 234 | WP_000006003.1 | DUF905 family protein | - |
K6149_RS28495 (93980) | 93980..94507 | - | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
K6149_RS29130 (94809) | 94809..95276 | + | 468 | Protein_123 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaKPC-2 / catA2 / blaCTX-M-65 / fosA3 / rmtB / blaTEM-1B | - | 1..153399 | 153399 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T213859 WP_001372321.1 NZ_CP082003:c90073-89948 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T213859 NZ_CP109890:1275898-1276179 [Xylella fastidiosa subsp. fastidiosa]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA
Antitoxin
Download Length: 225 bp
>AT213859 NZ_CP082003:c90374-90150 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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