Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 89948..90374 Replicon plasmid pKP18-1-KPC2
Accession NZ_CP082003
Organism Klebsiella pneumoniae strain KP18-1

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag K6149_RS28470 Protein ID WP_001372321.1
Coordinates 89948..90073 (-) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 90150..90374 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6149_RS28435 (85003) 85003..85230 - 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -
K6149_RS28440 (85324) 85324..86010 - 687 WP_015059009.1 PAS domain-containing protein -
K6149_RS28445 (86201) 86201..86584 - 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
K6149_RS28450 (86861) 86861..87508 + 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
K6149_RS28455 (87805) 87805..88626 - 822 WP_001234445.1 DUF932 domain-containing protein -
K6149_RS28460 (88737) 88737..89033 - 297 WP_001272251.1 hypothetical protein -
K6149_RS28465 (89333) 89333..89629 + 297 Protein_115 hypothetical protein -
K6149_RS28470 (89948) 89948..90073 - 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
K6149_RS29125 (90015) 90015..90164 - 150 Protein_117 plasmid maintenance protein Mok -
- (90150) 90150..90374 - 225 NuclAT_0 - Antitoxin
- (90150) 90150..90374 - 225 NuclAT_0 - Antitoxin
- (90150) 90150..90374 - 225 NuclAT_0 - Antitoxin
- (90150) 90150..90374 - 225 NuclAT_0 - Antitoxin
K6149_RS28475 (90386) 90386..91105 - 720 WP_001276217.1 plasmid SOS inhibition protein A -
K6149_RS28480 (91102) 91102..91536 - 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
K6149_RS28485 (91605) 91605..93628 - 2024 Protein_120 ParB/RepB/Spo0J family partition protein -
K6149_RS28490 (93689) 93689..93922 - 234 WP_000006003.1 DUF905 family protein -
K6149_RS28495 (93980) 93980..94507 - 528 WP_000290834.1 single-stranded DNA-binding protein -
K6149_RS29130 (94809) 94809..95276 + 468 Protein_123 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 / catA2 / blaCTX-M-65 / fosA3 / rmtB / blaTEM-1B - 1..153399 153399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T213859 WP_001372321.1 NZ_CP082003:c90073-89948 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp

>T213859 NZ_CP109890:1275898-1276179 [Xylella fastidiosa subsp. fastidiosa]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA

Antitoxin


Download         Length: 225 bp

>AT213859 NZ_CP082003:c90374-90150 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References