Detailed information of TA system TA213817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2837091..2837745
• Replicon: chromosome
• Accession: NZ_CP081944
• Organism: Pseudomonas sp. DR208

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: K5K89_RS12910
• Protein ID: WP_093513166.1
• Coordinates: 2837395..2837745 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1H0L908
• Locus tag: K5K89_RS12905
• Protein ID: WP_071491908.1
• Coordinates: 2837091..2837405 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5K89_RS12880 (K5K89_12880)	2832407..2833441	-	1035	WP_071491912.1	methionine synthase	-
K5K89_RS12885 (K5K89_12885)	2833469..2834452	-	984	WP_222541556.1	DUF1852 domain-containing protein	-
K5K89_RS12890 (K5K89_12890)	2834667..2834903	-	237	WP_058425027.1	hypothetical protein	-
K5K89_RS12895 (K5K89_12895)	2835024..2835857	+	834	WP_071491910.1	arylamine N-acetyltransferase	-
K5K89_RS12900 (K5K89_12900)	2835984..2836736	+	753	WP_093123849.1	outer membrane beta-barrel protein	-
K5K89_RS12905 (K5K89_12905)	2837091..2837405	-	315	WP_071491908.1	transcriptional regulator	Antitoxin
K5K89_RS12910 (K5K89_12910)	2837395..2837745	-	351	WP_093513166.1	toxin	Toxin
K5K89_RS12915 (K5K89_12915)	2837986..2839449	-	1464	WP_058425023.1	NADH-quinone oxidoreductase subunit NuoN	-
K5K89_RS12920 (K5K89_12920)	2839457..2840989	-	1533	WP_010209575.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13830.74 Da
• Isoelectric Point: 9.3833

>T213817 WP_093513166.1 NZ_CP081944:c2837745-2837395 [Pseudomonas sp. DR208]
MDALFIELPPFERHRKDYLSDELFQGFQQELMKNPEAGDVIEGTGGLRKVRFIDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQDDLTPQHKKALKHMLDREIKARTHHET

Nucleotide

• Length: 351 bp

>T213817 NZ_CP109874:c2639017-2638841 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11771.53 Da
• Isoelectric Point: 10.4449

>AT213817 WP_071491908.1 NZ_CP081944:c2837405-2837091 [Pseudomonas sp. DR208]
MKREIFSELVEGFDALANERQGKVTLRTHKVHLNQLEPLTAEEVVAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAATLIRLVARFPETVAQLAALG

Nucleotide

• Length: 315 bp

>AT213817 NZ_CP109874:c2638795-2638379 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1H0L908