Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3721503..3722082 Replicon chromosome
Accession NZ_CP081943
Organism Pseudomonas sp. MM213

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5R88_RS16890 Protein ID WP_226298077.1
Coordinates 3721503..3721781 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5R88_RS16895 Protein ID WP_192228018.1
Coordinates 3721795..3722082 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5R88_RS16870 (K5R88_16765) 3717001..3717168 - 168 WP_008028899.1 DUF2474 domain-containing protein -
K5R88_RS16875 (K5R88_16770) 3717244..3718251 - 1008 WP_008028900.1 cytochrome d ubiquinol oxidase subunit II -
K5R88_RS16880 (K5R88_16775) 3718255..3719697 - 1443 WP_008040295.1 cytochrome ubiquinol oxidase subunit I -
K5R88_RS16885 (K5R88_16780) 3720178..3721416 + 1239 WP_192228016.1 MFS transporter -
K5R88_RS16890 (K5R88_16785) 3721503..3721781 + 279 WP_226298077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5R88_RS16895 (K5R88_16790) 3721795..3722082 + 288 WP_192228018.1 HigA family addiction module antitoxin Antitoxin
K5R88_RS16900 (K5R88_16795) 3722089..3722640 - 552 WP_207285511.1 DJ-1/PfpI family protein -
K5R88_RS16905 (K5R88_16800) 3722707..3723153 - 447 WP_226298078.1 DUF4879 domain-containing protein -
K5R88_RS16910 (K5R88_16805) 3723376..3724671 + 1296 WP_008028910.1 NCS2 family permease -
K5R88_RS16915 (K5R88_16810) 3724668..3725747 + 1080 WP_192228019.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
K5R88_RS16920 (K5R88_16815) 3725938..3726849 + 912 WP_008028916.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-89)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10724.35 Da        Isoelectric Point: 10.0873

>T213811 WP_226298077.1 NZ_CP081943:3721503-3721781 [Pseudomonas sp. MM213]
MIKSFQHKGLRGFYETGSTRGIRANHAKRLSRMLQFMDRAMAPGDLDLPGWRLHPLRGELAEFWALSVSGNWRVIFRFIG
SDIELVDYLDYH

Download         Length: 279 bp

>T213811 NZ_CP109874:c843414-843037 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10571.28 Da        Isoelectric Point: 7.1424

>AT213811 WP_192228018.1 NZ_CP081943:3721795-3722082 [Pseudomonas sp. MM213]
MPLHNPPHPGETLLMDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARMWLGVQTDYDLWQA
EQREQPVIKPLAVHA

Download         Length: 288 bp

>AT213811 NZ_CP109874:c843872-843504 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References