Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 338641..339276 Replicon chromosome
Accession NZ_CP081939
Organism Avibacterium paragallinarum strain p4chr1

Toxin (Protein)


Gene name higB Uniprot ID A0A0F5EY10
Locus tag K5O18_RS01615 Protein ID WP_017806021.1
Coordinates 338641..338946 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5O18_RS01620 Protein ID WP_046098498.1
Coordinates 338956..339276 (+) Length 107 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O18_RS01595 (K5O18_01595) 333816..335075 - 1260 WP_110478584.1 glutamate-5-semialdehyde dehydrogenase -
K5O18_RS01600 (K5O18_01600) 335084..335755 - 672 WP_046097465.1 trimeric intracellular cation channel family protein -
K5O18_RS01605 (K5O18_01605) 335918..336736 + 819 WP_017806023.1 hypothetical protein -
K5O18_RS01610 (K5O18_01610) 337174..338529 + 1356 WP_194742916.1 outer membrane protein transport protein -
K5O18_RS01615 (K5O18_01615) 338641..338946 + 306 WP_017806021.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5O18_RS01620 (K5O18_01620) 338956..339276 + 321 WP_046098498.1 HigA family addiction module antitoxin Antitoxin
K5O18_RS01625 (K5O18_01625) 339323..339862 + 540 WP_017806019.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
K5O18_RS01630 (K5O18_01630) 339884..340552 + 669 WP_017806018.1 DNA mismatch repair endonuclease MutH -
K5O18_RS01635 (K5O18_01635) 340692..341414 + 723 WP_017806017.1 TerC family protein -
K5O18_RS01640 (K5O18_01640) 341570..342103 - 534 WP_017806016.1 disulfide bond formation protein DsbB -
K5O18_RS01645 (K5O18_01645) 342116..343657 - 1542 WP_017806015.1 Na(+)/H(+) antiporter NhaB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-99)

Antitoxin

(6-84)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 12192.01 Da        Isoelectric Point: 9.5601

>T213801 WP_017806021.1 NZ_CP081939:338641-338946 [Avibacterium paragallinarum]
MFNLTAKHFKDDYLYRFFQYGELHSKIPMTLSKVLARKLDMINAAENLNDLRSPPANRLELLEPKENKRYSIRVNKQYRL
IFHFDNGELSQLYLDPHRYDL

Download         Length: 306 bp

>T213801 NZ_CP109856:c4429962-4429207 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12055.83 Da        Isoelectric Point: 6.8792

>AT213801 WP_046098498.1 NZ_CP081939:338956-339276 [Avibacterium paragallinarum]
MFPTQRKPTSVGEILQEEFLLPLNLKINDLAEILDVHRNTASNLVSNHSKVTLEMAVKLAKAFGTSPEFWINLQNAVDLW
ELNHNDRFQQSLSKVKIAHYPPAFSV

Download         Length: 321 bp

>AT213801 NZ_CP109856:c4430464-4430096 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0F5EY10


Antitoxin

Source ID Structure

References