Detailed information of TA system TA021380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3533712..3534282
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: graT
• Uniprot ID: Q2RPT1
• Locus tag: RRU_RS15850
• Protein ID: WP_011390817.1
• Coordinates: 3534004..3534282 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: RRU_RS15845
• Protein ID: WP_011390816.1
• Coordinates: 3533712..3533999 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS15825	3530089..3531780	+	1692	WP_011390812.1	isovaleryl-CoA dehydrogenase	-
RRU_RS15830	3531969..3532265	+	297	WP_011390813.1	helix-turn-helix domain-containing protein	-
RRU_RS15835	3532429..3533025	+	597	WP_011390814.1	NAD(P)H-dependent oxidoreductase	-
RRU_RS15840	3533037..3533636	+	600	WP_011390815.1	TetR/AcrR family transcriptional regulator	-
RRU_RS15845	3533712..3533999	-	288	WP_011390816.1	HigA family addiction module antidote protein	Antitoxin
RRU_RS15850	3534004..3534282	-	279	WP_011390817.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RRU_RS15855	3534592..3535068	-	477	WP_011390818.1	Lrp/AsnC family transcriptional regulator	-
RRU_RS15860	3535202..3536137	+	936	WP_011390819.1	DMT family transporter	-
RRU_RS15865	3536238..3538559	+	2322	WP_011390820.1	mechanosensitive ion channel	-
RRU_RS15870	3538519..3539238	-	720	WP_011390821.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (13-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10630.96 Da
• Isoelectric Point: 6.4553

>T21380 WP_011390817.1 NC_007643:c3534282-3534004 [Rhodospirillum rubrum ATCC 11170]
MIKTAADKRTAKFLTGQRVSDFQAFERQAQRRVAILNEATCIEDLMKLPSNRFEALSGGRDGQFSIRINDQWRICFTFHE
GDAYDAEIVDYH

Nucleotide

• Length: 279 bp

>T21380 NC_007643:c3534282-3534004 [Rhodospirillum rubrum ATCC 11170]
ATGATAAAAACCGCAGCCGACAAGCGCACGGCCAAGTTCCTTACCGGACAGCGGGTATCGGACTTCCAGGCTTTCGAGCG
CCAAGCACAGCGACGGGTGGCCATCCTTAATGAAGCCACCTGTATCGAAGACCTGATGAAACTCCCGTCCAACCGCTTCG
AGGCGCTAAGCGGGGGGCGCGACGGCCAGTTCAGCATCCGCATCAACGACCAATGGCGGATTTGCTTCACCTTCCACGAG
GGAGATGCCTATGACGCCGAAATCGTCGATTATCATTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 9994.49 Da
• Isoelectric Point: 7.2014

>AT21380 WP_011390816.1 NC_007643:c3533999-3533712 [Rhodospirillum rubrum ATCC 11170]
VALPPLHPGEFLADELTEIGVSVSALARALDVPQSRMADIVAGKRSVTADTALRLAAYFGTSARLWLNLQAAYDLAITQA
KEGAHIASVVRPRAA

Nucleotide

• Length: 288 bp

>AT21380 NC_007643:c3533999-3533712 [Rhodospirillum rubrum ATCC 11170]
GTGGCGCTGCCGCCCCTGCATCCGGGTGAATTTCTGGCCGATGAACTAACCGAGATCGGCGTATCGGTATCGGCGCTGGC
GCGCGCCCTTGATGTACCCCAGAGCCGCATGGCCGATATCGTCGCCGGCAAGCGATCGGTTACCGCCGACACGGCTCTGC
GCCTTGCCGCCTATTTCGGCACATCGGCCCGGCTGTGGCTGAACCTCCAGGCGGCTTACGACCTTGCGATCACCCAAGCC
AAAGAAGGCGCCCATATCGCCTCCGTCGTCCGTCCCCGGGCGGCCTGA

Structures

Toxin

• AlphaFold DB: Q2RPT1