Detailed information of TA system TA213791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3840436..3841033
• Replicon: chromosome
• Accession: NZ_CP081897
• Organism: Klebsiella pneumoniae strain MN-03

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A9J6S5A1
• Locus tag: KZ659_RS18940
• Protein ID: WP_004893639.1
• Coordinates: 3840716..3841033 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: R4YH91
• Locus tag: KZ659_RS18935
• Protein ID: WP_004142561.1
• Coordinates: 3840436..3840723 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ659_RS18905 (KZ659_18825)	3836516..3836764	+	249	WP_002893037.1	DUF1158 domain-containing protein	-
KZ659_RS18910 (KZ659_18830)	3836782..3837123	-	342	WP_002893035.1	RamA family antibiotic efflux transcriptional regulator	-
KZ659_RS18915 (KZ659_18835)	3837154..3838269	-	1116	WP_012737592.1	MBL fold metallo-hydrolase	-
KZ659_RS18920 (KZ659_18840)	3838449..3839030	+	582	WP_004176968.1	TetR/AcrR family transcriptional regulator	-
KZ659_RS18925 (KZ659_18845)	3839030..3839398	+	369	WP_004142557.1	MmcQ/YjbR family DNA-binding protein	-
KZ659_RS18930 (KZ659_18850)	3839518..3840171	+	654	WP_004178896.1	oxygen-insensitive NAD(P)H nitroreductase	-
KZ659_RS18935 (KZ659_18855)	3840436..3840723	-	288	WP_004142561.1	helix-turn-helix transcriptional regulator	Antitoxin
KZ659_RS18940 (KZ659_18860)	3840716..3841033	-	318	WP_004893639.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ659_RS18945 (KZ659_18865)	3841218..3842261	-	1044	WP_004893645.1	DUF2157 domain-containing protein	-
KZ659_RS18950 (KZ659_18870)	3842927..3843793	-	867	WP_004151823.1	helix-turn-helix transcriptional regulator	-
KZ659_RS18955 (KZ659_18875)	3843902..3845329	+	1428	WP_004176980.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-88)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12100.35 Da
• Isoelectric Point: 11.2767

>T213791 WP_004893639.1 NZ_CP081897:c3841033-3840716 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Nucleotide

• Length: 318 bp

>T213791 NZ_CP109853:c4124467-4123157 [Pantoea dispersa]
ATGACAGAACTGGATGTCTACATGAACGGCTATCGGACAGGCGTTTTCAGCAGGGCAGCAACCGGTGCACACACCTTCAG
ATATTATGAGAGCTGGCTGAATCAGCCGGGTAGCCGACCGATATCCCTCTCCATGCCTTTGCGCCACCAGCCTTACAAGG
GCGCGGAGGTCTATAACTTTTTTGATAACCTGCTGCCTGATAACCCTGAAATTCGCGCACGTATTCTGTCTCGCTATCAG
GCCAGCTCCACCCAGCCCTTTGACTTACTGGCAAAAGTCGGCAGCGACACCATTGGTGCGCTGCAATTGTTACCGCCTGA
CAGTAAACCGCACACTGTCCGAACGATCGATTATCGCCGGTTAAGCGATAGCGAACTGGAAAAAATCCTTTCAGGCTATC
AGTCAGGCGCACCGCTTGGCATGCTGGAAGAGCTGACTGATTTTCGTATTTCACTGGCTGGCGCGCAGGAGAAAACGGCG
CTGTTACGCATTGATCAACAATGGTGCCTGCCGCAGGGCAATACGCCCACCACCCACATTTTAAAATTGCCGATTGGCAA
TATTCAGAGCCATTCGCATCGCATCGATCTTTCAGATAGCGTGGAGAATGAGTGGCTTTGTACGCTGATTGCCAGAGAAT
TTGGCCTGAAAGTTCCCCCTTGCTTTATCGTAAACACCGGGAAAATTAAAGCACTGGCCGTGGAGCGGTTTGATCGGCGT
TATGCATCGGATGGACAGTGGATCATGCGGTTACCCCAGGAAGATTTTTGTCAGGTGCTGAATGTACCCGCGGCAGGAAA
ATATGAAAGCCACGGCGGCCCGGGCATTTCTGCGATTATGGATTATCTCCTGAATTCAGTTAATGCAGAACAGGATCGAT
ATGATTTCATGAAAGCTCAGGTCCTGTTTTGGCTGCTGGCGGCCACCGATGGCCATGCCAAAAACTTTTCTATTTTTATC
GAAGCGGAAGGACGTTTTCGCCTGACGCCGTTTTACGACATCCTTTCCATTTATCCCGTGATTGGCGGTGCGGGATTACA
CATTCGTGATGCAAAGCTGGCAATGGGACTGAACGGGAGCAAAGGCCGGAAAGCCGCCATTGAACACATTTTCCCGCGCC
ATTTTATAGAAACCGCAAAAACGACAAAATTTGCCCTGACGGCGATGGCACATATCCTCGATGAGTTCAGAGCCAGGACG
CCAGAAGTGATCCAACGCGTGCAGGAGCAAATCCCTGCAGCCTTCCCGTTACGCGTGAGCCAGACCATCCTCAATGGCTT
TAAGGCGCGGGCCGCGCGTCTGCAGCAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10771.46 Da
• Isoelectric Point: 10.2212

>AT213791 WP_004142561.1 NZ_CP081897:c3840723-3840436 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Nucleotide

• Length: 288 bp

>AT213791 NZ_CP109853:c4124724-4124467 [Pantoea dispersa]
ATGAAAATCACCAGCGCCAAACAATTAAGTTCTTATCTCAAAGATAGAAGACTCACAGAGGCACTCTCGCAAGCGAAAGT
TGCCAGCAAAATTGGTATTCGCCAGGATACCGTCTCGAGCTTTGAGCTACAGCCTGAAACCACCCGACTGGACACGCTGT
TTCGTATTCTCGCTGCTCTGGATCTGGAAATGGAGATAAAACCCCGTGGTTTGCCATCGGCCAAACAGGACCCGGACGGC
TGGAAGGAGGAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0S3DIQ1