Detailed information of TA system TA021379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2332700..2333294
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q2RSS5
• Locus tag: RRU_RS10475
• Protein ID: WP_011389773.1
• Coordinates: 2333013..2333294 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: RRU_RS10470
• Protein ID: WP_011389772.1
• Coordinates: 2332700..2332999 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS10440	2328282..2329886	-	1605	WP_011389767.1	ABC transporter substrate-binding protein	-
RRU_RS10445	2330185..2331186	+	1002	WP_011389768.1	DnaJ domain-containing protein	-
RRU_RS10450	2331183..2331521	+	339	WP_011389769.1	hypothetical protein	-
RRU_RS10460	2331798..2332040	-	243	WP_011389770.1	hypothetical protein	-
RRU_RS10465	2332122..2332511	+	390	WP_011389771.1	type II toxin-antitoxin system HicB family antitoxin	-
RRU_RS10470	2332700..2332999	-	300	WP_011389772.1	HigA family addiction module antidote protein	Antitoxin
RRU_RS10475	2333013..2333294	-	282	WP_011389773.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RRU_RS10480	2333738..2334478	-	741	WP_011389774.1	endonuclease/exonuclease/phosphatase family protein	-
RRU_RS10485	2334684..2334896	+	213	WP_011389775.1	hypothetical protein	-
RRU_RS10490	2335348..2337819	+	2472	WP_011389776.1	HAMP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10852.29 Da
• Isoelectric Point: 8.1381

>T21379 WP_011389773.1 NC_007643:c2333294-2333013 [Rhodospirillum rubrum ATCC 11170]
MIRSFADKDTEGLFHGRFARKLPHDIQRIAQRKLRQIHAAEVLTDLRAPPGNHLEALQRDRAGQHSIRINDQWRICFVWK
DGGAEDVEIVDYH

Nucleotide

• Length: 282 bp

>T21379 NC_007643:c2333294-2333013 [Rhodospirillum rubrum ATCC 11170]
ATGATCCGATCGTTCGCAGACAAGGATACCGAGGGGCTTTTTCACGGGCGTTTTGCCCGTAAGCTGCCCCACGATATCCA
ACGCATCGCCCAGCGCAAGCTGCGGCAGATCCATGCCGCCGAAGTGCTGACCGACCTGCGAGCGCCCCCGGGCAACCACC
TGGAGGCCCTGCAACGGGACCGGGCCGGGCAGCACAGCATCAGGATCAATGACCAATGGCGCATCTGTTTTGTTTGGAAA
GACGGCGGTGCCGAAGATGTTGAAATCGTCGACTACCACTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11242.93 Da
• Isoelectric Point: 5.8632

>AT21379 WP_011389772.1 NC_007643:c2332999-2332700 [Rhodospirillum rubrum ATCC 11170]
MTIRDLSPVHPGEQLREEFMKPLKISAYKLAKDIDVPVSRIQDLAAERRSVTGDTALRLSRYFGTTPEFWLNMQRDFDLE
VAEIAVGDQIIAKVQPRAA

Nucleotide

• Length: 300 bp

>AT21379 NC_007643:c2332999-2332700 [Rhodospirillum rubrum ATCC 11170]
ATGACCATCAGGGATCTCTCCCCCGTCCATCCCGGCGAACAGCTTCGGGAGGAGTTCATGAAGCCGCTGAAAATCAGCGC
CTATAAGTTGGCCAAAGACATCGACGTTCCGGTTAGCCGCATCCAGGATCTGGCCGCCGAGCGGCGGTCCGTCACCGGCG
ACACCGCTCTGCGCCTCTCCCGATATTTCGGCACCACCCCGGAATTCTGGCTGAATATGCAGCGAGATTTCGACCTGGAA
GTCGCCGAGATCGCCGTGGGCGATCAGATCATCGCCAAGGTGCAGCCCCGCGCCGCCTGA

Structures

Toxin

• AlphaFold DB: Q2RSS5