Detailed information of TA system TA021377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1255763..1256376
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q2RVI0
• Locus tag: RRU_RS05560
• Protein ID: WP_011388819.1
• Coordinates: 1255763..1256059 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: RRU_RS05565
• Protein ID: WP_014626089.1
• Coordinates: 1256068..1256376 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS05520	1250984..1251166	+	183	WP_014626086.1	DUF1192 family protein	-
RRU_RS05525	1251265..1252044	+	780	WP_011388812.1	3-hydroxybutyrate dehydrogenase	-
RRU_RS05530	1252054..1252509	+	456	WP_011388813.1	acyl-CoA thioesterase	-
RRU_RS05535	1252513..1253496	-	984	WP_011388814.1	aldo/keto reductase	-
RRU_RS05540	1253602..1254537	+	936	WP_011388815.1	LysR family transcriptional regulator	-
RRU_RS05545	1254632..1254847	+	216	WP_011388816.1	ribbon-helix-helix domain-containing protein	-
RRU_RS05550	1254841..1255206	+	366	WP_011388817.1	type II toxin-antitoxin system VapC family toxin	-
RRU_RS05555	1255244..1255588	+	345	WP_011388818.1	transcriptional regulator	-
RRU_RS05560	1255763..1256059	+	297	WP_011388819.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RRU_RS05565	1256068..1256376	+	309	WP_014626089.1	HigA family addiction module antidote protein	Antitoxin
RRU_RS05570	1256531..1257316	+	786	WP_011388821.1	ATP-binding cassette domain-containing protein	-
RRU_RS05575	1257313..1258014	+	702	WP_011388822.1	cobalamin biosynthesis protein	-
RRU_RS05580	1258016..1259197	+	1182	WP_011388823.1	cysteine desulfurase	-
RRU_RS05585	1259241..1259966	+	726	WP_011388824.1	Fe-S cluster protein	-
RRU_RS05590	1260070..1260540	-	471	WP_011388825.1	Hsp20 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-70)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11623.24 Da
• Isoelectric Point: 6.4797

>T21377 WP_011388819.1 NC_007643:1255763-1256059 [Rhodospirillum rubrum ATCC 11170]
MIVGFRDEWLRAFFVEDIHCRSIPADLESRLFRKLQMIDDAMTDQDLRVPPSNHFEKLHGILDGLYSIRVNKQWRLIFRW
DGGRGEASGIYLDDHGYR

Nucleotide

• Length: 297 bp

>T21377 NC_007643:1255763-1256059 [Rhodospirillum rubrum ATCC 11170]
ATGATCGTTGGATTTCGCGATGAATGGCTGCGGGCCTTTTTCGTGGAGGATATCCACTGCCGCAGTATTCCTGCCGATCT
CGAAAGCCGATTGTTCCGAAAGCTCCAGATGATCGACGATGCGATGACCGATCAGGATTTGCGCGTGCCGCCCAGCAATC
ATTTCGAAAAACTACATGGCATCCTTGATGGCCTGTATTCGATTCGCGTCAACAAGCAATGGCGGCTGATCTTTCGATGG
GACGGCGGTCGCGGCGAAGCGTCGGGCATTTATCTCGACGACCACGGTTATCGGTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11509.47 Da
• Isoelectric Point: 10.5835

>AT21377 WP_014626089.1 NC_007643:1256068-1256376 [Rhodospirillum rubrum ATCC 11170]
MMMTKRKPVTVGEILVEEFMGPLGLTQAALAEAMGVQRKHVNELCNNRRTVTAATALILARVFGNSPDFWLNAQRRNDLW
EVLHSPKDVERIERAKPLALRA

Nucleotide

• Length: 309 bp

>AT21377 NC_007643:1256068-1256376 [Rhodospirillum rubrum ATCC 11170]
ATGATGATGACCAAGCGCAAGCCGGTGACGGTCGGGGAAATCCTGGTGGAAGAGTTCATGGGGCCGCTTGGCCTGACGCA
GGCGGCGCTGGCCGAGGCGATGGGCGTTCAGCGCAAACATGTCAACGAGCTGTGCAATAATCGACGCACCGTCACGGCGG
CGACCGCGCTTATTCTGGCCCGCGTATTTGGCAATAGCCCGGACTTCTGGCTGAACGCGCAGCGGCGGAACGACCTGTGG
GAGGTTCTGCACAGTCCCAAGGACGTGGAGCGTATCGAGCGCGCCAAACCCTTGGCGCTGCGGGCTTAA

Structures

Toxin

• AlphaFold DB: Q2RVI0