Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 709557..710332 | Replicon | chromosome |
Accession | NZ_CP081896 | ||
Organism | Klebsiella pneumoniae strain PA-01 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A332L402 |
Locus tag | KZ665_RS03495 | Protein ID | WP_021314147.1 |
Coordinates | 709847..710332 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | W8UEW1 |
Locus tag | KZ665_RS03490 | Protein ID | WP_004150912.1 |
Coordinates | 709557..709850 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZ665_RS03470 (KZ665_03470) | 704765..705367 | - | 603 | WP_032448122.1 | short chain dehydrogenase | - |
KZ665_RS03475 (KZ665_03475) | 705465..706376 | + | 912 | WP_021314148.1 | LysR family transcriptional regulator | - |
KZ665_RS03480 (KZ665_03480) | 706377..707525 | - | 1149 | WP_064179254.1 | PLP-dependent aspartate aminotransferase family protein | - |
KZ665_RS03485 (KZ665_03485) | 707536..708912 | - | 1377 | WP_004174417.1 | pyridoxal-phosphate dependent enzyme | - |
KZ665_RS03490 (KZ665_03490) | 709557..709850 | + | 294 | WP_004150912.1 | DUF1778 domain-containing protein | Antitoxin |
KZ665_RS03495 (KZ665_03495) | 709847..710332 | + | 486 | WP_021314147.1 | GNAT family N-acetyltransferase | Toxin |
KZ665_RS03500 (KZ665_03500) | 711036..711674 | + | 639 | Protein_688 | hypothetical protein | - |
KZ665_RS03505 (KZ665_03505) | 711722..711938 | + | 217 | Protein_689 | transposase | - |
KZ665_RS03515 (KZ665_03515) | 712616..713329 | - | 714 | WP_002916694.1 | DUF554 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 711722..711874 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17621.68 Da Isoelectric Point: 8.5144
>T213761 WP_021314147.1 NZ_CP081896:709847-710332 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
Download Length: 486 bp
>T213761 NZ_CP109846:3071655-3071963 [Providencia rettgeri]
ATGCAATATTGCCTCTATCAAAATCGAGAAGATACAGTCAAACACCCATATTTACTGGACATTCAAAGTAATATTATTGA
TATATTGAATACTCTTTTAGTCATCCCGTTATTCGATAGCAGGCTAGCTAAAAAACCATTACCTACTTGCCTTAACCCCC
AGTTATTTAGCAACGGGCAGGTGTTTGTTTTAATGACACACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTGAACTGCCAACAAAACACGATTAAACACGCAATTGACTTACTTATTGATGGCTTTTAA
ATGCAATATTGCCTCTATCAAAATCGAGAAGATACAGTCAAACACCCATATTTACTGGACATTCAAAGTAATATTATTGA
TATATTGAATACTCTTTTAGTCATCCCGTTATTCGATAGCAGGCTAGCTAAAAAACCATTACCTACTTGCCTTAACCCCC
AGTTATTTAGCAACGGGCAGGTGTTTGTTTTAATGACACACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTGAACTGCCAACAAAACACGATTAAACACGCAATTGACTTACTTATTGATGGCTTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10901.46 Da Isoelectric Point: 6.3783
>AT213761 WP_004150912.1 NZ_CP081896:709557-709850 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
Download Length: 294 bp
>AT213761 NZ_CP109846:3071455-3071655 [Providencia rettgeri]
ATCACTGTAGCGCCTGAGCTCTGCGAACAAGCAAGGCGGGCTAAACTCAACTTATCTGCAATACTAACTTGTGCCTTACA
AGCTGAATTAAAACGCCTAGAAGCACAAAAGTGGAAAAATGAAAATATCGAAGGTTTTAATCAATTAAATAGGAACAATG
AAGAATACGGATTACTCTCAGATAAATACAAGGGTTTTTAA
ATCACTGTAGCGCCTGAGCTCTGCGAACAAGCAAGGCGGGCTAAACTCAACTTATCTGCAATACTAACTTGTGCCTTACA
AGCTGAATTAAAACGCCTAGAAGCACAAAAGTGGAAAAATGAAAATATCGAAGGTTTTAATCAATTAAATAGGAACAATG
AAGAATACGGATTACTCTCAGATAAATACAAGGGTTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A332L402 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GVL4 |