Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3735574..3736171 Replicon chromosome
Accession NZ_CP081895
Organism Klebsiella quasipneumoniae strain MN-07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KZ661_RS18425 Protein ID WP_087827241.1
Coordinates 3735854..3736171 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZ661_RS18420 Protein ID WP_049013658.1
Coordinates 3735574..3735861 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ661_RS18390 (3731762) 3731762..3732010 + 249 WP_002893037.1 DUF1158 domain-containing protein -
KZ661_RS18395 (3732028) 3732028..3732369 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
KZ661_RS18400 (3732400) 3732400..3733515 - 1116 WP_074423618.1 MBL fold metallo-hydrolase -
KZ661_RS18405 (3733695) 3733695..3734279 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
KZ661_RS18410 (3734276) 3734276..3734644 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
KZ661_RS18415 (3734764) 3734764..3735417 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
KZ661_RS18420 (3735574) 3735574..3735861 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
KZ661_RS18425 (3735854) 3735854..3736171 - 318 WP_087827241.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ661_RS18430 (3736356) 3736356..3737399 - 1044 WP_101989644.1 DUF2157 domain-containing protein -
KZ661_RS18435 (3737915) 3737915..3738781 - 867 WP_032454966.1 helix-turn-helix transcriptional regulator -
KZ661_RS18440 (3738890) 3738890..3740317 + 1428 WP_087827239.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12049.33 Da        Isoelectric Point: 10.9540

>T213757 WP_087827241.1 NZ_CP081895:c3736171-3735854 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEICLALKRLEEMRNE

Download         Length: 318 bp

>T213757 NZ_CP109845:c5919437-5919159 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT213757 WP_049013658.1 NZ_CP081895:c3735861-3735574 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT213757 NZ_CP109845:c5919147-5918842 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References