Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1796534..1797194 Replicon chromosome
Accession NZ_CP081893
Organism Klebsiella quasipneumoniae strain WI-06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KZ658_RS08720 Protein ID WP_049092199.1
Coordinates 1796841..1797194 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZ658_RS08715 Protein ID WP_072413418.1
Coordinates 1796534..1796836 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ658_RS08685 (1791647) 1791647..1792918 - 1272 WP_223065729.1 integrase arm-type DNA-binding domain-containing protein -
KZ658_RS08700 (1793367) 1793367..1794803 + 1437 WP_223065730.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
KZ658_RS08710 (1795167) 1795167..1796098 + 932 Protein_1698 integrase arm-type DNA-binding domain-containing protein -
KZ658_RS08715 (1796534) 1796534..1796836 - 303 WP_072413418.1 XRE family transcriptional regulator Antitoxin
KZ658_RS08720 (1796841) 1796841..1797194 - 354 WP_049092199.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ658_RS08725 (1797691) 1797691..1797912 - 222 WP_047738806.1 helix-turn-helix transcriptional regulator -
KZ658_RS08730 (1797909) 1797909..1798370 - 462 WP_049004530.1 hypothetical protein -
KZ658_RS08735 (1798775) 1798775..1800541 + 1767 WP_228744820.1 ATP-binding protein -
KZ658_RS08740 (1800587) 1800587..1801555 - 969 WP_223065399.1 IS5 family transposase -
KZ658_RS08745 (1801577) 1801577..1801846 - 270 WP_228744821.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1800587..1801510 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13456.40 Da        Isoelectric Point: 9.9199

>T213716 WP_049092199.1 NZ_CP081893:c1797194-1796841 [Klebsiella quasipneumoniae]
MWTIKTTDTFDRWFASLSDTDRVSMLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGAPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

>T213716 NZ_CP109833:1871003-1871590 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11030.77 Da        Isoelectric Point: 5.7316

>AT213716 WP_072413418.1 NZ_CP081893:c1796836-1796534 [Klebsiella quasipneumoniae]
MGRTLEQLIADEKSEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT213716 NZ_CP109833:1871657-1872511 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGCC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References