Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 755978..756753 Replicon chromosome
Accession NZ_CP081892
Organism Klebsiella pneumoniae strain NY-06

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag KZ657_RS03800 Protein ID WP_021314147.1
Coordinates 756268..756753 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag KZ657_RS03795 Protein ID WP_004150912.1
Coordinates 755978..756271 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ657_RS03775 (751188) 751188..751790 - 603 WP_009308651.1 short chain dehydrogenase -
KZ657_RS03780 (751888) 751888..752799 + 912 WP_040188863.1 LysR family transcriptional regulator -
KZ657_RS03785 (752800) 752800..753948 - 1149 WP_069376269.1 PLP-dependent aspartate aminotransferase family protein -
KZ657_RS03790 (753959) 753959..755335 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
KZ657_RS03795 (755978) 755978..756271 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
KZ657_RS03800 (756268) 756268..756753 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
KZ657_RS03805 (757457) 757457..758049 + 593 Protein_748 hypothetical protein -
KZ657_RS03810 (758146) 758146..758362 + 217 Protein_749 transposase -
KZ657_RS03820 (758877) 758877..759590 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 758146..758298 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T213697 WP_021314147.1 NZ_CP081892:756268-756753 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T213697 NZ_CP109812:c282572-282282 [Stenotrophomonas sp. SBJS02]
ATGGCGATTCTCCAGGCAACAGAGACATTCACGCGATGGCTGCGTGGACTCAACGACAGCAGGGCCCGCGGCGTGATCGT
GGAGCGCCTGCAGCGCGTCGCCCGCGGTCTCGAGGGAGATGTCCGATCAGTGGGTCATGGCGTAAGCGAACTGCGAATCA
ACCATGGGCCGGGATATCGCGTGTATTTCACACGTCGTGGGAGATCCATCGTCGTGCTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCGGTCAGGCTCGCGGAGCTGCTGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT213697 WP_004150912.1 NZ_CP081892:755978-756271 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT213697 NZ_CP109812:c282243-281950 [Stenotrophomonas sp. SBJS02]
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCAGACTATCTGGATGATGACGTCGCAATCGCCGCCTATCTAAGCGA
GGCGTTGGCAGCAGGTGACGCGGGCCACTTCCAGGAGGCACTCGGAACAGTGGCGCGCGCCCGCGGCATGGGCGGCGTTG
CCGAGGTCTCCGGCCTGGGACGCGAAAGCCTGTACAAGGCGCTGCGCCCCGGAGCACACCCACGCTTCGATACCGTGCAA
CGTGTGCTGTCGGCGCTTGGGGTGCATCTGACCGTGCAGGCCGGCAAGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References