Detailed information of TA system TA213696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 355575..356221
• Replicon: chromosome
• Accession: NZ_CP081892
• Organism: Klebsiella pneumoniae strain NY-06

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KZ657_RS01640
• Protein ID: WP_064158923.1
• Coordinates: 355575..355922 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1F2LZT5
• Locus tag: KZ657_RS01645
• Protein ID: WP_008806992.1
• Coordinates: 355922..356221 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ657_RS01630 (351501)	351501..352934	+	1434	WP_002920564.1	glycogen synthase GlgA	-
KZ657_RS01635 (352952)	352952..355399	+	2448	WP_002920561.1	glycogen phosphorylase	-
KZ657_RS01640 (355575)	355575..355922	+	348	WP_064158923.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ657_RS01645 (355922)	355922..356221	+	300	WP_008806992.1	XRE family transcriptional regulator	Antitoxin
KZ657_RS01650 (356284)	356284..357792	-	1509	WP_002920554.1	glycerol-3-phosphate dehydrogenase	-
KZ657_RS01655 (357997)	357997..358326	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
KZ657_RS01660 (358377)	358377..359207	+	831	WP_004151408.1	rhomboid family intramembrane serine protease GlpG	-
KZ657_RS01665 (359257)	359257..360015	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-84)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13597.64 Da
• Isoelectric Point: 6.2327

>T213696 WP_064158923.1 NZ_CP081892:355575-355922 [Klebsiella pneumoniae]
MWYVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T213696 NZ_CP109812:c282243-281950 [Stenotrophomonas sp. SBJS02]
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCAGACTATCTGGATGATGACGTCGCAATCGCCGCCTATCTAAGCGA
GGCGTTGGCAGCAGGTGACGCGGGCCACTTCCAGGAGGCACTCGGAACAGTGGCGCGCGCCCGCGGCATGGGCGGCGTTG
CCGAGGTCTCCGGCCTGGGACGCGAAAGCCTGTACAAGGCGCTGCGCCCCGGAGCACACCCACGCTTCGATACCGTGCAA
CGTGTGCTGTCGGCGCTTGGGGTGCATCTGACCGTGCAGGCCGGCAAGGCCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10814.61 Da
• Isoelectric Point: 10.1464

>AT213696 WP_008806992.1 NZ_CP081892:355922-356221 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Nucleotide

• Length: 300 bp

>AT213696 NZ_CP109812:c282572-282282 [Stenotrophomonas sp. SBJS02]
ATGGCGATTCTCCAGGCAACAGAGACATTCACGCGATGGCTGCGTGGACTCAACGACAGCAGGGCCCGCGGCGTGATCGT
GGAGCGCCTGCAGCGCGTCGCCCGCGGTCTCGAGGGAGATGTCCGATCAGTGGGTCATGGCGTAAGCGAACTGCGAATCA
ACCATGGGCCGGGATATCGCGTGTATTTCACACGTCGTGGGAGATCCATCGTCGTGCTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCGGTCAGGCTCGCGGAGCTGCTGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1F2LZT5