Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 329387..329973 Replicon chromosome
Accession NZ_CP081892
Organism Klebsiella pneumoniae strain NY-06

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KZ657_RS01530 Protein ID WP_223098603.1
Coordinates 329605..329973 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag KZ657_RS01525 Protein ID WP_004174006.1
Coordinates 329387..329608 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ657_RS01505 (325544) 325544..326470 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
KZ657_RS01510 (326467) 326467..327744 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
KZ657_RS01515 (327741) 327741..328508 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
KZ657_RS01520 (328510) 328510..329223 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
KZ657_RS01525 (329387) 329387..329608 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZ657_RS01530 (329605) 329605..329973 + 369 WP_223098603.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KZ657_RS01535 (330246) 330246..331562 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
KZ657_RS01540 (331669) 331669..332556 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
KZ657_RS01545 (332553) 332553..333398 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
KZ657_RS01550 (333400) 333400..334470 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 324373..335207 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13582.95 Da        Isoelectric Point: 8.6410

>T213695 WP_223098603.1 NZ_CP081892:329605-329973 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDSNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T213695 NZ_CP109811:228436-228786 [Mesobacillus jeotgali]
TTGATTGTCAAACGTGGTGACGTCTATTTTGCGGACCTATCCCCAGTTGTTGGTTCAGAGCAAGGCGGAGTGCGCCCTGT
CCTGGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTCATTATCGCAGCGATCACAGCACAGATCCAAAAAG
CCAAGCTTCCTACTCATGTAGAGATAGATGCGAAGCGGTATGGTTTTGAACGAGACTCGGTCATCTTATTGGAACAGATA
CGCACAATTGACAAACAGCGCCTAACCGATAAAATTACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCCT
TCAGGTAAGTTTAGGTCTTATCGAATTTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT213695 WP_004174006.1 NZ_CP081892:329387-329608 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT213695 NZ_CP109811:228150-228431 [Mesobacillus jeotgali]
GTGTCTGAATCCAGCGCAACAACTGAGATTTTGGTAAAGTTACCGCAGCATCTTTTAAGTGAACTAGATGGATTTGTTAA
GCAAGAGAACGTAAACCGCAGCGAATTTATTTATCAGGCAACAAAAATGTTTTTGCGTGAGAAGAAAAAGAGACAAATTC
GTGAATCCATGAGACGTGGCTATATGGAAATGGCCAAGATTAATTTGACCATTGCATCTGAAGCATTTCAAGCAGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References