21369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475160..2475683 Replicon chromosome
Accession NC_007622
Organism Staphylococcus aureus RF122

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SAB_RS12650 Protein ID WP_001067424.1
Coordinates 2475160..2475426 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag SAB_RS12655 Protein ID WP_000587621.1
Coordinates 2475426..2475683 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAB_RS12630 2470371..2471555 - 1185 WP_000026197.1 MFS transporter -
SAB_RS12635 2471951..2472727 - 777 WP_000072158.1 iron export ABC transporter permease subunit FetB -
SAB_RS12640 2472720..2473382 - 663 WP_000923510.1 ATP-binding cassette domain-containing protein -
SAB_RS12645 2473728..2474804 - 1077 WP_001072887.1 M42 family metallopeptidase -
SAB_RS12650 2475160..2475426 - 267 WP_001067424.1 Txe/YoeB family addiction module toxin Toxin
SAB_RS12655 2475426..2475683 - 258 WP_000587621.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAB_RS12665 2476042..2476497 + 456 WP_000732077.1 YehR family lipoprotein -
SAB_RS12670 2476665..2478242 - 1578 WP_000143497.1 FMN-binding glutamate synthase family protein -
SAB_RS12675 2478436..2479185 + 750 WP_000072450.1 hypothetical protein -
SAB_RS12680 2479409..2480602 - 1194 WP_000675394.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10725.40 Da        Isoelectric Point: 10.1384

>T21369 WP_001067424.1 NC_007622:c2475426-2475160 [Staphylococcus aureus RF122]
MNNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T21369 NC_007622:c2475426-2475160 [Staphylococcus aureus RF122]
ATGAACAATTACACGGTTAAGATAAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT21369 WP_000587621.1 NC_007622:c2475683-2475426 [Staphylococcus aureus RF122]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKNIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT21369 NC_007622:c2475683-2475426 [Staphylococcus aureus RF122]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAATATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References