Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2418818..2419335 Replicon chromosome
Accession NC_007622
Organism Staphylococcus aureus RF122

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag SAB_RS12350 Protein ID WP_000113263.1
Coordinates 2418818..2419084 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAB_RS12355 Protein ID WP_000584499.1
Coordinates 2419084..2419335 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAB_RS12325 2414048..2414584 - 537 WP_000185902.1 GNAT family N-acetyltransferase -
SAB_RS12330 2415028..2415852 - 825 WP_000594632.1 formate/nitrite transporter family protein -
SAB_RS12335 2416055..2416237 - 183 WP_000079137.1 hypothetical protein -
SAB_RS12340 2416324..2416791 - 468 WP_000153337.1 SRPBCC domain-containing protein -
SAB_RS12345 2416977..2418524 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAB_RS12350 2418818..2419084 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
SAB_RS12355 2419084..2419335 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAB_RS12360 2419499..2419599 - 101 Protein_2337 hypothetical protein -
SAB_RS12365 2419606..2420205 - 600 WP_000162810.1 DsbA family protein -
SAB_RS12370 2420224..2420586 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAB_RS12375 2420841..2422090 + 1250 Protein_2340 FemA/FemB family glycyltransferase FmhA -
SAB_RS12380 2422187..2422918 - 732 WP_000615463.1 amino acid ABC transporter ATP-binding protein -
SAB_RS12385 2422915..2423634 - 720 WP_000479577.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T21366 WP_000113263.1 NC_007622:c2419084-2418818 [Staphylococcus aureus RF122]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T21366 NC_007622:c2419084-2418818 [Staphylococcus aureus RF122]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT21366 WP_000584499.1 NC_007622:c2419335-2419084 [Staphylococcus aureus RF122]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT21366 NC_007622:c2419335-2419084 [Staphylococcus aureus RF122]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References