Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 790304..790997 | Replicon | chromosome |
| Accession | NZ_CP081881 | ||
| Organism | Escherichia coli strain WW2 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | S1EZG2 |
| Locus tag | K5O11_RS03825 | Protein ID | WP_000415584.1 |
| Coordinates | 790304..790600 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | S1EBV2 |
| Locus tag | K5O11_RS03830 | Protein ID | WP_000650107.1 |
| Coordinates | 790602..790997 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5O11_RS03790 (785392) | 785392..785706 | - | 315 | WP_000958598.1 | putative quinol monooxygenase | - |
| K5O11_RS03795 (785737) | 785737..786318 | - | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
| K5O11_RS03800 (786637) | 786637..786969 | + | 333 | WP_023149630.1 | DUF2645 family protein | - |
| K5O11_RS03805 (787015) | 787015..788364 | - | 1350 | WP_000673402.1 | quorum sensing histidine kinase QseC | - |
| K5O11_RS03810 (788361) | 788361..789020 | - | 660 | WP_001221493.1 | quorum sensing response regulator transcription factor QseB | - |
| K5O11_RS03815 (789172) | 789172..789564 | + | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
| K5O11_RS03820 (789617) | 789617..790099 | + | 483 | WP_000183505.1 | GyrI-like domain-containing protein | - |
| K5O11_RS03825 (790304) | 790304..790600 | + | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
| K5O11_RS03830 (790602) | 790602..790997 | + | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
| K5O11_RS03835 (791130) | 791130..792737 | + | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
| K5O11_RS03840 (792875) | 792875..795133 | + | 2259 | WP_001281841.1 | DNA topoisomerase IV subunit A | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T213605 WP_000415584.1 NZ_CP081881:790304-790600 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T213605 NZ_CP109727:c2140348-2139875 [Enterobacter roggenkampii]
ATGATTTTTTATCGTCTGGTGACAGGACGCTATGCCAGCGAGGCGTGGAGTGGGAGTGGTGCAAATCAGTATGGCGGACG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTCTCCACCTCCATCTCGCTGGCCTCACTGGAGATTTTGGTACATGTCA
GAAAAGATACCGTGCTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATAGATTACCTGGATAAAGCG
TGGCTCCCTGAGGATTGGCAGGAAAATCCGGCGCCGGTATCGACAATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
TGCCCTCGCGCTTATCTTACCTTCCTATATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGGCGTTCC
ACTCGGCGCTCAATTCAGTTCAGCAACTCCCCTTTATTTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
ATGATTTTTTATCGTCTGGTGACAGGACGCTATGCCAGCGAGGCGTGGAGTGGGAGTGGTGCAAATCAGTATGGCGGACG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTCTCCACCTCCATCTCGCTGGCCTCACTGGAGATTTTGGTACATGTCA
GAAAAGATACCGTGCTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATAGATTACCTGGATAAAGCG
TGGCTCCCTGAGGATTGGCAGGAAAATCCGGCGCCGGTATCGACAATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
TGCCCTCGCGCTTATCTTACCTTCCTATATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGGCGTTCC
ACTCGGCGCTCAATTCAGTTCAGCAACTCCCCTTTATTTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT213605 WP_000650107.1 NZ_CP081881:790602-790997 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT213605 NZ_CP109727:c2140788-2140345 [Enterobacter roggenkampii]
ATGAGAACATGGATCCCCGCACAGAAACCTGCTGATAACGCACTTTGGCGTTACGCCGGTTTACCCGCCAACCGAGGTAT
GCGGTTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTGCTCGACAACATCCACGAGTGGACGTCCATGTCGAAAG
CGGACATTTTGCGTGTCACGGGTATCAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGTTAACGCCCGAC
GAGAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCCGTTGACTATTTTGGCAGTAAAGAAGAAGCATGGAC
CTGGCTGCAGGCACCGGTGCGCGGACTGGGGAACATGGCGCCCGTCGACTTAATAGCGACGGAAACCGGTGCGCTGGAAG
TCACCGATTTGATTGGTCGCCTGGAACACGGCGTGTTCGCATGA
ATGAGAACATGGATCCCCGCACAGAAACCTGCTGATAACGCACTTTGGCGTTACGCCGGTTTACCCGCCAACCGAGGTAT
GCGGTTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTGCTCGACAACATCCACGAGTGGACGTCCATGTCGAAAG
CGGACATTTTGCGTGTCACGGGTATCAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGTTAACGCCCGAC
GAGAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCCGTTGACTATTTTGGCAGTAAAGAAGAAGCATGGAC
CTGGCTGCAGGCACCGGTGCGCGGACTGGGGAACATGGCGCCCGTCGACTTAATAGCGACGGAAACCGGTGCGCTGGAAG
TCACCGATTTGATTGGTCGCCTGGAACACGGCGTGTTCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|