Detailed information of TA system TA021356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2511678..2512455
• Replicon: chromosome
• Accession: NC_007614
• Organism: Nitrosospira multiformis ATCC 25196

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q2Y6X0
• Locus tag: NMUL_RS11530
• Protein ID: WP_011381507.1
• Coordinates: 2511678..2511980 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: NMUL_RS11535
• Protein ID: WP_011381508.1
• Coordinates: 2511982..2512455 (+)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMUL_RS15020	2506892..2509678	-	2787	WP_049783118.1	PAS domain S-box protein	-
NMUL_RS11525	2509828..2510871	+	1044	WP_011380592.1	IS481 family transposase	-
NMUL_RS11530	2511678..2511980	+	303	WP_011381507.1	type II toxin-antitoxin system MqsR family toxin	Toxin
NMUL_RS11535	2511982..2512455	+	474	WP_011381508.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
NMUL_RS11540	2512467..2512964	+	498	WP_011381509.1	type II toxin-antitoxin system MqsA family antitoxin	-
NMUL_RS11545	2513126..2513491	-	366	WP_167535587.1	DUF1493 family protein	-
NMUL_RS11550	2513497..2514114	-	618	WP_041352582.1	RHS repeat-associated core domain-containing protein	-
NMUL_RS16215	2514139..2514276	-	138	WP_011381512.1	hypothetical protein	-
NMUL_RS11560	2514979..2515674	+	696	WP_011381513.1	Bax inhibitor-1/YccA family protein	-
NMUL_RS11565	2515783..2517102	-	1320	WP_011381514.1	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2509828..2510871	1043

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (3-99)

Antitoxin

• Antitoxin MqsA (3-133)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11645.42 Da
• Isoelectric Point: 9.9792

>T21356 WP_011381507.1 NC_007614:2511678-2511980 [Nitrosospira multiformis ATCC 25196]
MDKSKPHYELDKVKSLIRAGQYRITRVASEGGDKLGFKNTQEIAEFVLTLKRTDFYKSMTSNMNHKEWQDVYHGDGPTKK
VVYLKFIVTNDVLILSFKEK

Nucleotide

• Length: 303 bp

>T21356 NC_007614:2511678-2511980 [Nitrosospira multiformis ATCC 25196]
ATGGACAAGAGCAAACCACATTACGAACTGGACAAGGTCAAAAGCTTAATACGCGCTGGTCAGTATCGGATAACAAGAGT
CGCAAGCGAAGGCGGCGACAAGCTAGGTTTTAAAAACACCCAAGAGATCGCGGAATTCGTGCTAACGCTGAAACGCACCG
ATTTCTATAAAAGCATGACAAGCAACATGAACCACAAGGAATGGCAAGACGTGTATCACGGCGACGGGCCAACGAAAAAA
GTGGTTTACCTGAAATTCATTGTCACGAACGACGTATTGATACTTTCCTTTAAGGAGAAATGA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17964.30 Da
• Isoelectric Point: 7.0860

>AT21356 WP_011381508.1 NC_007614:2511982-2512455 [Nitrosospira multiformis ATCC 25196]
MRCSLCGKGEVVAGTRDVPFTYKGQKTFIKNIRGEYCNRCGEGYYGPEHDGDILMAGYREFREKVDTVLAEQATFVEQVR
KKLGLDQREAGEIFGGGVNAFSRYETGKVRTPVSVMQLFTLLDRHPELLEEIRQNRYRTRGTQELREEVSAQKELTD

Nucleotide

• Length: 474 bp

>AT21356 NC_007614:2511982-2512455 [Nitrosospira multiformis ATCC 25196]
ATGAGATGTTCACTGTGCGGGAAGGGCGAGGTGGTAGCGGGTACCCGCGATGTGCCCTTTACCTATAAGGGCCAAAAAAC
CTTTATTAAAAATATTCGGGGGGAGTACTGCAACCGCTGCGGCGAGGGTTACTATGGCCCGGAGCACGATGGCGATATTC
TCATGGCCGGATACCGCGAGTTCAGAGAAAAAGTCGATACTGTGCTGGCCGAGCAGGCCACATTCGTGGAGCAGGTGCGG
AAGAAACTGGGGCTCGACCAGCGTGAAGCAGGGGAGATTTTTGGCGGCGGAGTGAATGCCTTTTCGCGTTATGAGACTGG
AAAAGTCAGAACACCGGTCTCTGTCATGCAGCTGTTCACGCTACTCGACCGGCACCCTGAGCTACTTGAGGAAATCAGGC
AGAATAGATATCGGACCAGGGGTACACAGGAGCTTCGTGAGGAAGTATCCGCGCAGAAGGAACTGACGGATTGA

Structures

Toxin

• AlphaFold DB: Q2Y6X0