Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4072647..4072905 Replicon chromosome
Accession NZ_CP081791
Organism Escherichia coli strain CT01

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag J6O14_RS20245 Protein ID WP_000809168.1
Coordinates 4072753..4072905 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4072647..4072704 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O14_RS20225 4067672..4069026 + 1355 Protein_3954 fimbria/pilus outer membrane usher protein -
J6O14_RS20230 4069039..4069998 + 960 WP_000871671.1 hypothetical protein -
J6O14_RS20235 4070036..4070935 - 900 WP_001300855.1 transcriptional activator NhaR -
J6O14_RS20240 4071001..4072167 - 1167 WP_057107799.1 Na+/H+ antiporter NhaA -
- 4072647..4072704 - 58 - - Antitoxin
J6O14_RS20245 4072753..4072905 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
J6O14_RS20250 4073009..4074139 - 1131 WP_001118464.1 molecular chaperone DnaJ -
J6O14_RS20255 4074228..4076144 - 1917 WP_000516135.1 molecular chaperone DnaK -
J6O14_RS20260 4076521..4076925 + 405 WP_000843559.1 DUF2541 family protein -
J6O14_RS20265 4076951..4077664 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T213448 WP_000809168.1 NZ_CP081791:4072753-4072905 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T213448 NZ_CP107720:c4508393-4508220 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 58 bp

>AT213448 NZ_CP081791:c4072704-4072647 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References