Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 775344..776037 Replicon chromosome
Accession NZ_CP081767
Organism Escherichia coli strain 0H18

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J6O59_RS03835 Protein ID WP_000415584.1
Coordinates 775344..775640 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J6O59_RS03840 Protein ID WP_000650107.1
Coordinates 775642..776037 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O59_RS03800 (770478) 770478..770957 + 480 WP_000065333.1 Hcp family type VI secretion system effector -
J6O59_RS03805 (770960) 770960..771670 + 711 WP_000834029.1 hypothetical protein -
J6O59_RS03810 (771677) 771677..772009 + 333 WP_000914691.1 DUF2645 family protein -
J6O59_RS03815 (772055) 772055..773404 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
J6O59_RS03820 (773401) 773401..774060 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
J6O59_RS03825 (774212) 774212..774604 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J6O59_RS03830 (774657) 774657..775139 + 483 WP_000609258.1 GyrI-like domain-containing protein -
J6O59_RS03835 (775344) 775344..775640 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J6O59_RS03840 (775642) 775642..776037 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J6O59_RS03845 (776170) 776170..777777 + 1608 WP_104457550.1 ABC transporter substrate-binding protein -
J6O59_RS03850 (777915) 777915..780173 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T213333 WP_000415584.1 NZ_CP081767:775344-775640 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T213333 NZ_CP107548:c2744776-2744471 [Pusillimonas sp. M17]
ATGACCAAGACAAGCAAGATTTCCGAGCTGCCGGAGTTCGACATGGCCGAAGTCCTCAAGACGGATGAGGACATTGCCAA
CTATCTGACGGTGGTTCTGGAAGAAAACGATCCCGCCGAGCTTTCCCATGCGCTGGGTGTCATTGCCCGCGCGCGTGGTA
TGACGGAAGTCGCGCGAGCCAGCGGTCTGACACGTGAGGCGCTCTATAAGGCATTGCGCCCTGGATCGCACCCGCGCTTC
GATACCATTGCCCGTGTATGCGCCGCGCTGGGTGTGCAACTGACTGCCCGGCCTGCGCATTCATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT213333 WP_000650107.1 NZ_CP081767:775642-776037 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT213333 NZ_CP107548:c2745078-2744782 [Pusillimonas sp. M17]
ATGTTCACAGTCAAGCAAACGCCGGAGTTCGAGCGATGGATTGGCGGCCTGAAGGATGGCATGGCTCGAATTCGCCTGGC
AAAGCGCTTGGATAAGGTTCAGCGCGGCAACCTGGGTGATGTGGCGCCGATAGGCGAGGGCGTCAGCGAAATGCGTGAAC
ACTTTGGTCCTGGCTGGCGAATGTATTACGTCCAGCGGGGCGATGTGTTGATTGTCATGCTGGGCGGCGGCGACAAGTCC
ACACAGAATGCCGATATCAAGCAGGCCATCGCGCTGGCGAAGACACTGCAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References