Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 819739..820432 Replicon chromosome
Accession NZ_CP081742
Organism Escherichia coli strain CX15

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J6O52_RS04070 Protein ID WP_000415584.1
Coordinates 819739..820035 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J6O52_RS04075 Protein ID WP_000650107.1
Coordinates 820037..820432 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O52_RS04035 (814873) 814873..815352 + 480 WP_000065333.1 Hcp family type VI secretion system effector -
J6O52_RS04040 (815355) 815355..816065 + 711 WP_000834029.1 hypothetical protein -
J6O52_RS04045 (816072) 816072..816404 + 333 WP_000914691.1 DUF2645 family protein -
J6O52_RS04050 (816450) 816450..817799 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
J6O52_RS04055 (817796) 817796..818455 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
J6O52_RS04060 (818607) 818607..818999 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J6O52_RS04065 (819052) 819052..819534 + 483 WP_000609258.1 GyrI-like domain-containing protein -
J6O52_RS04070 (819739) 819739..820035 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J6O52_RS04075 (820037) 820037..820432 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J6O52_RS04080 (820565) 820565..822172 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
J6O52_RS04085 (822310) 822310..824568 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T213272 WP_000415584.1 NZ_CP081742:819739-820035 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T213272 NZ_CP107508:c4904502-4904218 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT213272 WP_000650107.1 NZ_CP081742:820037-820432 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT213272 NZ_CP107508:c4904734-4904492 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References