Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 250067..250608 Replicon chromosome
Accession NC_007606
Organism Shigella dysenteriae Sd197

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag SDY_RS01240 Protein ID WP_000615980.1
Coordinates 250067..250345 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag SDY_RS01245 Protein ID WP_000729709.1
Coordinates 250348..250608 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SDY_RS01225 247649..248227 + 579 WP_011378551.1 D-sedoheptulose 7-phosphate isomerase -
SDY_RS01230 248433..249200 + 768 WP_000333379.1 class II glutamine amidotransferase -
SDY_RS01235 249171..249911 - 741 WP_001225679.1 murein L,D-transpeptidase -
SDY_RS01240 250067..250345 - 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
SDY_RS01245 250348..250608 - 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
SDY_RS01250 250818..251567 + 750 WP_011378552.1 C40 family peptidase -
SDY_RS01255 251743..252060 + 318 Protein_243 transposase -
SDY_RS01260 252117..252811 + 695 WP_134801557.1 IS1-like element IS1N family transposase -
SDY_RS01265 253042..253386 + 345 Protein_245 fimbria/pilus periplasmic chaperone -
SDY_RS01270 253441..254138 + 698 Protein_246 IS1 family transposase -
SDY_RS01280 254427..254639 - 213 Protein_247 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA / fimC 235981..256396 20415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T21316 WP_000615980.1 NC_007606:c250345-250067 [Shigella dysenteriae Sd197]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T21316 NC_007606:c250345-250067 [Shigella dysenteriae Sd197]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAGG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT21316 WP_000729709.1 NC_007606:c250608-250348 [Shigella dysenteriae Sd197]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT21316 NC_007606:c250608-250348 [Shigella dysenteriae Sd197]
ATGGCTGCAAATGCATTTGTTCGTGCCCGAATCGATGAGGATTTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References