Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 741416..742109 Replicon chromosome
Accession NZ_CP081711
Organism Escherichia coli strain AH21

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J6O42_RS03645 Protein ID WP_000415584.1
Coordinates 741416..741712 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J6O42_RS03650 Protein ID WP_000650107.1
Coordinates 741714..742109 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O42_RS03610 (736504) 736504..736818 - 315 WP_000958598.1 putative quinol monooxygenase -
J6O42_RS03615 (736849) 736849..737430 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
J6O42_RS03620 (737749) 737749..738081 + 333 WP_000917684.1 DUF2645 family protein -
J6O42_RS03625 (738127) 738127..739476 - 1350 WP_000673401.1 quorum sensing histidine kinase QseC -
J6O42_RS03630 (739473) 739473..740132 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
J6O42_RS03635 (740284) 740284..740676 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J6O42_RS03640 (740729) 740729..741211 + 483 WP_000183505.1 GyrI-like domain-containing protein -
J6O42_RS03645 (741416) 741416..741712 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J6O42_RS03650 (741714) 741714..742109 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J6O42_RS03655 (742242) 742242..743849 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
J6O42_RS03660 (743987) 743987..746245 + 2259 WP_032191348.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T213154 WP_000415584.1 NZ_CP081711:741416-741712 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T213154 NZ_CP107473:3608921-3609328 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT213154 WP_000650107.1 NZ_CP081711:741714-742109 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT213154 NZ_CP107473:3608674-3608940 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References