Detailed information of TA system TA213148

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4072652..4072910
• Replicon: chromosome
• Accession: NZ_CP081706
• Organism: Escherichia coli strain AH04

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: J6O21_RS20260
• Protein ID: WP_000809168.1
• Coordinates: 4072758..4072910 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4072652..4072709 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O21_RS20240	4067677..4069031	+	1355	Protein_3958	fimbria/pilus outer membrane usher protein	-
J6O21_RS20245	4069044..4070003	+	960	WP_000871671.1	hypothetical protein	-
J6O21_RS20250	4070041..4070940	-	900	WP_001300855.1	transcriptional activator NhaR	-
J6O21_RS20255	4071006..4072172	-	1167	WP_057107799.1	Na+/H+ antiporter NhaA	-
-	4072652..4072709	-	58	-	-	Antitoxin
J6O21_RS20260	4072758..4072910	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
J6O21_RS20265	4073014..4074144	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
J6O21_RS20270	4074233..4076149	-	1917	WP_000516135.1	molecular chaperone DnaK	-
J6O21_RS20275	4076526..4076930	+	405	WP_000843559.1	DUF2541 family protein	-
J6O21_RS20280	4076956..4077669	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T213148 WP_000809168.1 NZ_CP081706:4072758-4072910 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T213148 NZ_CP107473:c2071511-2070978 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT213148 NZ_CP081706:c4072709-4072652 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin