Detailed information of TA system TA021313

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 15394..15652
• Replicon: chromosome
• Accession: NC_007606
• Organism: Shigella dysenteriae Sd197

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: SDY_RS00075
• Protein ID: WP_038816461.1
• Coordinates: 15394..15546 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	15595..15652 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SDY_RS00055	10635..11348	-	714	WP_001102350.1	acidic protein MsyB	-
SDY_RS00060	11374..11778	-	405	WP_000843568.1	DUF2541 family protein	-
SDY_RS00065	12155..14071	+	1917	WP_000516135.1	molecular chaperone DnaK	-
SDY_RS00070	14160..15290	+	1131	WP_001118468.1	molecular chaperone DnaJ	-
SDY_RS00075	15394..15546	-	153	WP_038816461.1	type I toxin-antitoxin system toxin MokC	Toxin
-	15595..15652	+	58	-	-	Antitoxin
SDY_RS00080	15865..16558	-	694	Protein_15	IS1 family transposase	-
SDY_RS00085	16905..18071	+	1167	WP_000681370.1	Na+/H+ antiporter NhaA	-
SDY_RS00090	18137..19036	+	900	WP_001338226.1	transcriptional activator NhaR	-
SDY_RS00095	19074..19646	-	573	Protein_18	fimbrial family protein	-
SDY_RS00100	19712..20406	+	695	WP_087786203.1	IS1-like element IS1N family transposase	-
SDY_RS24555	20406..20513	-	108	Protein_20	fimbrial family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	15394..20836	5442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5530.56 Da
• Isoelectric Point: 7.1312

>T21313 WP_038816461.1 NC_007606:c15546-15394 [Shigella dysenteriae Sd197]
MKQHKAMIVALIVICITAVVAAQVTRKDLCEVHIRTGQTEIAVFTAYESE

Nucleotide

• Length: 153 bp

>T21313 NC_007606:c15546-15394 [Shigella dysenteriae Sd197]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCAGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGATTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT21313 NC_007606:15595-15652 [Shigella dysenteriae Sd197]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin