Detailed information of TA system TA213122

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 186912..187134
• Replicon: chromosome
• Accession: NZ_CP081706
• Organism: Escherichia coli strain AH04

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: J6O21_RS00895
• Protein ID: WP_001295224.1
• Coordinates: 187027..187134 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	186912..186970 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O21_RS00870	182300..183283	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
J6O21_RS00875	183280..184284	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
J6O21_RS00880	184314..185585	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
J6O21_RS00885	186061..186168	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
J6O21_RS00890	186544..186651	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	186912..186970	-	59	-	-	Antitoxin
J6O21_RS00895	187027..187134	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
J6O21_RS00900	187510..187617	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
J6O21_RS00905	187704..189383	-	1680	WP_000191613.1	cellulose biosynthesis protein BcsG	-
J6O21_RS00910	189380..189571	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
J6O21_RS00915	189568..190590	-	1023	Protein_180	cellulose biosynthesis protein BcsE	-
J6O21_RS00920	190646..191343	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
J6O21_RS00925	191360..191482	+	123	Protein_182	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T213122 WP_001295224.1 NZ_CP081706:187027-187134 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T213122 NZ_CP107463:c4897380-4897096 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT213122 NZ_CP081706:c186970-186912 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin