Detailed information of TA system TA212966

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 59139..59353
• Replicon: plasmid pE006-TC-121
• Accession: NZ_CP081506
• Organism: Enterococcus faecalis strain E006xJH2-2-TC1

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: K4752_RS14375
• Protein ID: WP_002360667.1
• Coordinates: 59243..59353 (-)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	59139..59203 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4752_RS14355	54837..55853	-	1017	WP_033593833.1	replication initiator protein A	-
K4752_RS14360	56516..57367	+	852	WP_002362419.1	ParA family protein	-
K4752_RS14365	57377..57919	+	543	WP_086321354.1	hypothetical protein	-
K4752_RS14370	58704..59003	-	300	WP_010817802.1	hypothetical protein	-
-	59139..59203	+	65	-	-	Antitoxin
K4752_RS14375	59243..59353	-	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
K4752_RS14380	59848..60165	+	318	WP_002394802.1	heavy metal-binding domain-containing protein	-
K4752_RS14385	60201..60869	+	669	WP_002403283.1	CPBP family intramembrane metalloprotease	-
K4752_RS14390	60986..61240	+	255	WP_002394800.1	hypothetical protein	-
K4752_RS14395	61400..61633	-	234	WP_002394799.1	hypothetical protein	-
K4752_RS14400	61635..61919	-	285	WP_002394798.1	hypothetical protein	-
K4752_RS14405	61936..62556	-	621	WP_162500025.1	recombinase family protein	-
K4752_RS14410	62760..62990	+	231	WP_002362431.1	hypothetical protein	-
K4752_RS14415	62990..63331	+	342	WP_002362432.1	type II toxin-antitoxin system PemK/MazF family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(B) / ant(6)-Ia / aac(6')-aph(2'') / dfrG / lnu(G) / erm(A) / optrA / poxtA / fexB	prgB/asc10	1..121520	121520

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T212966 WP_002360667.1 NZ_CP081506:c59353-59243 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T212966 NZ_CP107417:2023365-2023467 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 65 bp

>AT212966 NZ_CP081506:59139-59203 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Structures

Antitoxin