Detailed information of TA system TA212961

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2791200..2791537
• Replicon: chromosome
• Accession: NZ_CP081505
• Organism: Enterococcus faecalis strain E006xJH2-2-TC1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: K4752_RS13605
• Protein ID: WP_002388634.1
• Coordinates: 2791200..2791343 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2791275..2791537 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4752_RS13585	2787290..2787928	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
K4752_RS13590	2788616..2790232	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
K4752_RS13595	2790450..2790647	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	-
K4752_RS13600	2790766..2790906	+	141	WP_073340360.1	putative holin-like toxin	-
K4752_RS13605	2791200..2791343	+	144	WP_002388634.1	putative holin-like toxin	Toxin
-	2791275..2791537	-	263	-	-	Antitoxin
K4752_RS13610	2791538..2795413	-	3876	Protein_2666	WxL domain-containing protein	-
K4752_RS13615	2795394..2795762	-	369	WP_002388636.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.25 Da
• Isoelectric Point: 10.3634

>T212961 WP_002388634.1 NZ_CP081505:2791200-2791343 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKKDNKK

Nucleotide

• Length: 144 bp

>T212961 NZ_CP107415:c4371-4057 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT212961 NZ_CP081505:c2791537-2791275 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTTTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin