Detailed information of TA system TA021296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 951815..952457
• Replicon: chromosome
• Accession: NC_007512
• Organism: Chlorobium luteolum DSM 273

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: PLUT_RS04370
• Protein ID: WP_041463803.1
• Coordinates: 952131..952457 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: PLUT_RS04365
• Protein ID: WP_011357574.1
• Coordinates: 951815..952138 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLUT_RS04335	947155..947664	+	510	WP_041463801.1	ADP-ribosylglycohydrolase family protein	-
PLUT_RS04340	947710..948282	+	573	WP_011357570.1	DUF1566 domain-containing protein	-
PLUT_RS04350	948743..950035	-	1293	WP_011357571.1	hypothetical protein	-
PLUT_RS04355	950028..950414	-	387	WP_049752417.1	hypothetical protein	-
PLUT_RS11445	950930..951127	-	198	WP_157858222.1	type II toxin-antitoxin system YafQ family toxin	-
PLUT_RS04360	951196..951459	-	264	WP_011357573.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
PLUT_RS04365	951815..952138	-	324	WP_011357574.1	helix-turn-helix transcriptional regulator	Antitoxin
PLUT_RS04370	952131..952457	-	327	WP_041463803.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLUT_RS04375	953301..953717	-	417	WP_011357576.1	hypothetical protein	-
PLUT_RS04380	953882..954463	-	582	WP_011357577.1	hypothetical protein	-
PLUT_RS11090	954589..955374	-	786	WP_011357578.1	hypothetical protein	-
PLUT_RS11695	955427..955621	-	195	Protein_849	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	946048..959924	13876

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-95)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12580.98 Da
• Isoelectric Point: 10.4714

>T21296 WP_041463803.1 NC_007512:c952457-952131 [Pelodictyon luteolum DSM 273]
MSHEIEYFHPRILKDIEAWPESIKIDYARLIELLMDYGPDLRMPHSKAMGNGLFEIRPKGKAGIGRAFFCFMQGKRIVIL
HAFIKKTQSTPKKELLIARKRMKEITHG

Nucleotide

• Length: 327 bp

>T21296 NC_007512:c952457-952131 [Pelodictyon luteolum DSM 273]
ATGAGCCATGAGATCGAATACTTCCATCCTCGCATCCTGAAAGACATTGAGGCCTGGCCAGAATCCATCAAGATCGATTA
TGCTCGCCTCATTGAGTTGCTGATGGATTACGGACCAGACCTCAGGATGCCCCACTCCAAGGCGATGGGCAACGGTCTAT
TTGAAATTCGCCCAAAGGGGAAAGCAGGAATCGGAAGGGCTTTTTTCTGTTTTATGCAGGGCAAAAGGATCGTGATTTTA
CATGCGTTCATCAAAAAAACACAGTCAACACCCAAAAAAGAACTACTGATCGCACGTAAGCGAATGAAGGAGATAACCCA
TGGATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11998.78 Da
• Isoelectric Point: 8.4788

>AT21296 WP_011357574.1 NC_007512:c952138-951815 [Pelodictyon luteolum DSM 273]
MDDLTYQPIKHDHQEFLRNAMESKEFKEGYDALEPKYTLIRELLAARKRSGMTQDAVASKIGTTKSAISRLEACGKHTPS
ITTLRKYAEAVGCDLIIKLEPKKSAEA

Nucleotide

• Length: 324 bp

>AT21296 NC_007512:c952138-951815 [Pelodictyon luteolum DSM 273]
ATGGATGACCTTACCTATCAGCCTATAAAGCACGACCATCAGGAATTCCTGCGTAACGCTATGGAAAGCAAGGAGTTCAA
GGAAGGCTATGATGCCCTTGAACCGAAGTACACCCTGATCAGAGAGTTACTGGCAGCACGCAAGCGTTCCGGCATGACAC
AGGACGCGGTTGCCAGCAAGATCGGCACGACCAAAAGTGCCATCTCACGGCTTGAAGCGTGCGGCAAACACACCCCTTCC
ATAACCACACTCAGGAAATATGCTGAAGCCGTTGGGTGTGACCTGATCATTAAACTTGAACCGAAGAAGTCCGCTGAAGC
CTGA