Detailed information of TA system TA212954

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2790766..2791026
• Replicon: chromosome
• Accession: NZ_CP081505
• Organism: Enterococcus faecalis strain E006xJH2-2-TC1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: K4752_RS13600
• Protein ID: WP_073340360.1
• Coordinates: 2790766..2790906 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2790880..2791026 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4752_RS13580	2786034..2787026	+	993	WP_002385136.1	biotin--[acetyl-CoA-carboxylase] ligase	-
K4752_RS13585	2787290..2787928	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
K4752_RS13590	2788616..2790232	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
K4752_RS13595	2790450..2790647	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	-
K4752_RS13600	2790766..2790906	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2790880..2791026	-	147	-	-	Antitoxin
K4752_RS13605	2791200..2791343	+	144	WP_002388634.1	putative holin-like toxin	-
K4752_RS13610	2791538..2795413	-	3876	Protein_2666	WxL domain-containing protein	-
K4752_RS13615	2795394..2795762	-	369	WP_002388636.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T212954 WP_073340360.1 NZ_CP081505:2790766-2790906 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T212954 NZ_CP107412:c5004555-5003638 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 147 bp

>AT212954 NZ_CP081505:c2791026-2790880 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCAAT
TGTATTATTTAAAAATAACCGTACTGGTCAAAGTAAACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin