212933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6335933..6336627 Replicon chromosome
Accession NZ_CP081490
Organism Pseudomonas protegens strain PS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K5F93_RS28680 Protein ID WP_213664620.1
Coordinates 6336331..6336627 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K5F93_RS28675 Protein ID WP_221809826.1
Coordinates 6335933..6336334 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5F93_RS28665 (K5F93_28665) 6331065..6334418 + 3354 WP_221809824.1 mechanosensitive channel MscK -
K5F93_RS28670 (K5F93_28670) 6334468..6335931 + 1464 WP_221809825.1 YdiU family protein -
K5F93_RS28675 (K5F93_28675) 6335933..6336334 - 402 WP_221809826.1 transcriptional regulator Antitoxin
K5F93_RS28680 (K5F93_28680) 6336331..6336627 - 297 WP_213664620.1 type II toxin-antitoxin system HigB family toxin Toxin
K5F93_RS28685 (K5F93_28685) 6336912..6337352 + 441 WP_221809827.1 IgaA/UmoB family intracellular growth attenuator -
K5F93_RS28690 (K5F93_28690) 6337438..6338382 + 945 WP_221809828.1 hypothetical protein -
K5F93_RS28695 (K5F93_28695) 6338409..6339359 + 951 WP_221809829.1 hypothetical protein -
K5F93_RS28700 (K5F93_28700) 6339438..6339872 + 435 WP_221809830.1 thioredoxin TrxC -
K5F93_RS28705 (K5F93_28705) 6339920..6340690 - 771 WP_102862830.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11433.27 Da        Isoelectric Point: 10.6515

>T212933 WP_213664620.1 NZ_CP081490:c6336627-6336331 [Pseudomonas protegens]
MHIITAKRIRQAKEQWPQVARALDTWYRKAKGARPADFADMKALFPALDKVGRFHVFDIGGNKLRLIAIVRYGGQRLYIR
HVLDHGEYDKGLWKEESQ

Download         Length: 297 bp

>T212933 NZ_CP107408:352943-353290 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14867.01 Da        Isoelectric Point: 4.4569

>AT212933 WP_221809826.1 NZ_CP081490:c6336334-6335933 [Pseudomonas protegens]
MSLQVKQAAEHWPFVAPILCKPKSEADYDALALALDELLDIMGEDESHPLASLVDIMGDWIEAYDEEHHPMPAVSAVEIL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFKVSMETFA

Download         Length: 402 bp

>AT212933 NZ_CP107408:353290-353589 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References