Detailed information of TA system TA212924

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4487656..4487876
• Replicon: chromosome
• Accession: NZ_CP081489
• Organism: Escherichia coli BL21(DE3)

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: K5T46_RS21755
• Protein ID: WP_000170963.1
• Coordinates: 4487656..4487763 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4487810..4487876 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5T46_RS21730	4482826..4483914	-	1089	Protein_4271	LacI family DNA-binding transcriptional regulator	-
K5T46_RS21735	4483900..4484918	-	1019	Protein_4272	IS3-like element IS150 family transposase	-
K5T46_RS21740	4484966..4486000	+	1035	Protein_4273	glutamate decarboxylase	-
K5T46_RS21745	4485939..4487030	-	1092	Protein_4274	elongation factor Tu	-
K5T46_RS21750	4487121..4487228	-	108	WP_000170963.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4487276..4487341	+	66	NuclAT_16	-	-
-	4487276..4487341	+	66	NuclAT_16	-	-
-	4487276..4487341	+	66	NuclAT_16	-	-
-	4487276..4487341	+	66	NuclAT_16	-	-
-	4487276..4487341	+	66	NuclAT_19	-	-
-	4487276..4487341	+	66	NuclAT_19	-	-
-	4487276..4487341	+	66	NuclAT_19	-	-
-	4487276..4487341	+	66	NuclAT_19	-	-
-	4487276..4487341	+	66	NuclAT_22	-	-
-	4487276..4487341	+	66	NuclAT_22	-	-
-	4487276..4487341	+	66	NuclAT_22	-	-
-	4487276..4487341	+	66	NuclAT_22	-	-
-	4487276..4487341	+	66	NuclAT_25	-	-
-	4487276..4487341	+	66	NuclAT_25	-	-
-	4487276..4487341	+	66	NuclAT_25	-	-
-	4487276..4487341	+	66	NuclAT_25	-	-
-	4487276..4487341	+	66	NuclAT_28	-	-
-	4487276..4487341	+	66	NuclAT_28	-	-
-	4487276..4487341	+	66	NuclAT_28	-	-
-	4487276..4487341	+	66	NuclAT_28	-	-
-	4487276..4487341	+	66	NuclAT_31	-	-
-	4487276..4487341	+	66	NuclAT_31	-	-
-	4487276..4487341	+	66	NuclAT_31	-	-
-	4487276..4487341	+	66	NuclAT_31	-	-
-	4487276..4487343	+	68	NuclAT_34	-	-
-	4487276..4487343	+	68	NuclAT_34	-	-
-	4487276..4487343	+	68	NuclAT_34	-	-
-	4487276..4487343	+	68	NuclAT_34	-	-
-	4487276..4487343	+	68	NuclAT_37	-	-
-	4487276..4487343	+	68	NuclAT_37	-	-
-	4487276..4487343	+	68	NuclAT_37	-	-
-	4487276..4487343	+	68	NuclAT_37	-	-
-	4487276..4487343	+	68	NuclAT_40	-	-
-	4487276..4487343	+	68	NuclAT_40	-	-
-	4487276..4487343	+	68	NuclAT_40	-	-
-	4487276..4487343	+	68	NuclAT_40	-	-
-	4487276..4487343	+	68	NuclAT_43	-	-
-	4487276..4487343	+	68	NuclAT_43	-	-
-	4487276..4487343	+	68	NuclAT_43	-	-
-	4487276..4487343	+	68	NuclAT_43	-	-
-	4487276..4487343	+	68	NuclAT_46	-	-
-	4487276..4487343	+	68	NuclAT_46	-	-
-	4487276..4487343	+	68	NuclAT_46	-	-
-	4487276..4487343	+	68	NuclAT_46	-	-
-	4487276..4487343	+	68	NuclAT_49	-	-
-	4487276..4487343	+	68	NuclAT_49	-	-
-	4487276..4487343	+	68	NuclAT_49	-	-
-	4487276..4487343	+	68	NuclAT_49	-	-
-	4487277..4487342	+	66	NuclAT_52	-	-
-	4487277..4487342	+	66	NuclAT_52	-	-
-	4487277..4487342	+	66	NuclAT_52	-	-
-	4487277..4487342	+	66	NuclAT_52	-	-
-	4487277..4487342	+	66	NuclAT_55	-	-
-	4487277..4487342	+	66	NuclAT_55	-	-
-	4487277..4487342	+	66	NuclAT_55	-	-
-	4487277..4487342	+	66	NuclAT_55	-	-
K5T46_RS21755	4487656..4487763	-	108	WP_000170963.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4487810..4487876	+	67	-	-	Antitoxin
K5T46_RS21760	4488100..4488207	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
K5T46_RS21765	4488583..4488690	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
K5T46_RS21770	4488947..4489644	+	698	WP_103215986.1	IS1-like element IS1A family transposase	-
K5T46_RS21775	4489660..4490307	+	648	Protein_4280	RHS element protein	-
K5T46_RS21780	4490299..4490433	+	135	Protein_4281	increased serum survival lipoprotein Iss	-
K5T46_RS21785	4490524..4490706	-	183	WP_001228695.1	prophage lysis lipoprotein RzoD	-
K5T46_RS21790	4491546..4491665	+	120	Protein_4283	IS3 family transposase	-
K5T46_RS21795	4491763..4491915	+	153	WP_000956455.1	type I toxin-antitoxin system toxin HokE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	aac(3)-Ia	tufA	4473030..4489644	16614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T212924 WP_000170963.1 NZ_CP081489:c4487763-4487656 [Escherichia coli BL21(DE3)]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T212924 NZ_CP107403:3061907-3062275 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT212924 NZ_CP081489:4487810-4487876 [Escherichia coli BL21(DE3)]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin