Detailed information of TA system TA212912

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2518329..2518549
• Replicon: chromosome
• Accession: NZ_CP081489
• Organism: Escherichia coli BL21(DE3)

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: K5T46_RS12050
• Protein ID: WP_000170963.1
• Coordinates: 2518442..2518549 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2518329..2518395 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5T46_RS12030	2514402..2515601	+	1200	WP_000284714.1	lipoprotein-releasing ABC transporter permease subunit LolC	-
K5T46_RS12035	2515594..2516295	+	702	WP_001033695.1	lipoprotein-releasing ABC transporter ATP-binding protein LolD	-
K5T46_RS12040	2516295..2517539	+	1245	WP_001251384.1	lipoprotein-releasing ABC transporter permease subunit LolE	-
K5T46_RS12045	2517568..2517996	+	429	Protein_2380	ROK family protein	-
-	2518329..2518395	-	67	-	-	Antitoxin
K5T46_RS12050	2518442..2518549	+	108	WP_000170963.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
K5T46_RS12055	2518696..2519550	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
K5T46_RS12060	2519586..2520395	-	810	WP_001257044.1	invasion regulator SirB1	-
K5T46_RS12065	2520399..2520791	-	393	WP_000200373.1	invasion regulator SirB2	-
K5T46_RS12070	2520788..2521621	-	834	WP_000456454.1	peptide chain release factor N(5)-glutamine methyltransferase	-
K5T46_RS12075	2521621..2522703	-	1083	WP_000804726.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T212912 WP_000170963.1 NZ_CP081489:2518442-2518549 [Escherichia coli BL21(DE3)]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T212912 NZ_CP107399:c125828-125412 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT212912 NZ_CP081489:c2518395-2518329 [Escherichia coli BL21(DE3)]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin