212888

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2843093..2843595 Replicon chromosome
Accession NZ_CP081477
Organism Pseudomonas aeruginosa strain P8W

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C7CBF7
Locus tag K5A80_RS13380 Protein ID WP_023081358.1
Coordinates 2843093..2843347 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C7C600
Locus tag K5A80_RS13385 Protein ID WP_004350479.1
Coordinates 2843344..2843595 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5A80_RS13360 (K5A80_13800) 2839528..2840391 + 864 WP_004350470.1 integrase domain-containing protein -
K5A80_RS13365 (K5A80_13805) 2840579..2840929 + 351 WP_023081356.1 hypothetical protein -
K5A80_RS13370 (K5A80_13810) 2840944..2842464 + 1521 WP_004350477.1 conjugal transfer protein TraG N-terminal domain-containing protein -
K5A80_RS13375 (K5A80_13815) 2842472..2842867 - 396 WP_023081357.1 DUF3742 family protein -
K5A80_RS13380 (K5A80_13820) 2843093..2843347 - 255 WP_023081358.1 Txe/YoeB family addiction module toxin Toxin
K5A80_RS13385 (K5A80_13825) 2843344..2843595 - 252 WP_004350479.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
K5A80_RS13390 (K5A80_13830) 2843818..2845050 - 1233 Protein_2661 tyrosine-type recombinase/integrase -
K5A80_RS13400 (K5A80_13840) 2845839..2846339 - 501 WP_003098996.1 DUF305 domain-containing protein -
K5A80_RS13405 (K5A80_13845) 2846790..2847536 + 747 WP_003098991.1 hypothetical protein -
K5A80_RS13410 (K5A80_13850) 2847655..2847867 + 213 WP_003090093.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10061.50 Da        Isoelectric Point: 8.4789

>T212888 WP_023081358.1 NZ_CP081477:c2843347-2843093 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY

Download         Length: 255 bp

>T212888 NZ_CP107394:c1858090-1857683 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.65 Da        Isoelectric Point: 4.5843

>AT212888 WP_004350479.1 NZ_CP081477:c2843595-2843344 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE

Download         Length: 252 bp

>AT212888 NZ_CP107394:c1858337-1858071 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7CBF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C600

References