Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1749351..1749988 Replicon chromosome
Accession NZ_CP081457
Organism Pseudomonas syringae pv. actinidifoliorum ICMP 18803

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A237_RS07960 Protein ID WP_017700479.1
Coordinates 1749674..1749988 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A237_RS07955 Protein ID WP_017703368.1
Coordinates 1749351..1749674 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A237_RS07930 (A237_007905) 1745205..1745897 - 693 WP_020341701.1 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO -
A237_RS07935 (A237_007910) 1745911..1746372 - 462 WP_004397572.1 DUF1456 family protein -
A237_RS07940 (A237_007915) 1746454..1747164 - 711 WP_004397570.1 rRNA pseudouridine synthase -
A237_RS07945 (A237_007920) 1747258..1747698 - 441 WP_005736177.1 GNAT family N-acetyltransferase -
A237_RS07950 (A237_007925) 1747800..1749143 - 1344 WP_004397566.1 30S ribosomal protein S12 methylthiotransferase RimO -
A237_RS07955 (A237_007930) 1749351..1749674 - 324 WP_017703368.1 helix-turn-helix domain-containing protein Antitoxin
A237_RS07960 (A237_007935) 1749674..1749988 - 315 WP_017700479.1 transcription elongation factor GreB Toxin
A237_RS07965 (A237_007940) 1750117..1751205 - 1089 WP_017700480.1 catalase family protein -
A237_RS07970 (A237_007945) 1751527..1753422 + 1896 WP_005736172.1 potassium transporter Kup -
A237_RS07975 (A237_007950) 1753517..1754851 - 1335 WP_017700481.1 AcvB/VirJ family lysyl-phosphatidylglycerol hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11914.77 Da        Isoelectric Point: 10.2260

>T212878 WP_017700479.1 NZ_CP081457:c1749988-1749674 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
MIFIETPVFSSDLKNHLDDEEYRSLQVHLAEHPKSGALIEDTGGLRKIRWAAHGKGKSGGVRVIYYHVSAHYQIRMILIY
RKGILDSLTDKQKAQLRALNKGWK

Download         Length: 315 bp

>T212878 NZ_CP107390:2804646-2805029 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12175.80 Da        Isoelectric Point: 8.8041

>AT212878 WP_017703368.1 NZ_CP081457:c1749674-1749351 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
MEKNLFDRLVESMTQMDEIDRGERQPSREFHIDAVQVKKIRQATGLSQVKFAKRIDVAVGTLRNWEQGRREPEGPARALL
RAIHNDPKHVLAALSSNGEELSETGRL

Download         Length: 324 bp

>AT212878 NZ_CP107390:2804404-2804646 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References