Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2590453..2590976 Replicon chromosome
Accession NZ_CP081354
Organism Staphylococcus aureus strain SQL1

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag K1X69_RS13030 Protein ID WP_000074048.1
Coordinates 2590453..2590719 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag K1X69_RS13035 Protein ID WP_000587616.1
Coordinates 2590719..2590976 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1X69_RS13010 (2585760) 2585760..2586947 - 1188 WP_000026194.1 MFS transporter -
K1X69_RS13015 (2587343) 2587343..2588119 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
K1X69_RS13020 (2588112) 2588112..2588774 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
K1X69_RS13025 (2589022) 2589022..2590098 - 1077 WP_001076671.1 M42 family metallopeptidase -
K1X69_RS13030 (2590453) 2590453..2590719 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
K1X69_RS13035 (2590719) 2590719..2590976 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1X69_RS13040 (2591082) 2591082..2591276 - 195 WP_001790145.1 hypothetical protein -
K1X69_RS13045 (2591335) 2591335..2591790 + 456 WP_000732082.1 DUF1307 domain-containing protein -
K1X69_RS13050 (2591958) 2591958..2593535 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
K1X69_RS13055 (2593730) 2593730..2594479 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
K1X69_RS13060 (2594703) 2594703..2595896 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T212875 WP_000074048.1 NZ_CP081354:c2590719-2590453 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T212875 NZ_CP107390:c1906805-1906398 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT212875 WP_000587616.1 NZ_CP081354:c2590976-2590719 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT212875 NZ_CP107390:c1907052-1906786 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References