Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2533605..2534122 Replicon chromosome
Accession NZ_CP081354
Organism Staphylococcus aureus strain SQL1

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag K1X69_RS12755 Protein ID WP_000113262.1
Coordinates 2533605..2533871 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag K1X69_RS12760 Protein ID WP_000584502.1
Coordinates 2533871..2534122 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1X69_RS12725 (2529031) 2529031..2529567 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
K1X69_RS12730 (2529800) 2529800..2530624 - 825 WP_000572040.1 formate/nitrite transporter family protein -
K1X69_RS12735 (2530841) 2530841..2531023 - 183 WP_000230294.1 hypothetical protein -
K1X69_RS12740 (2531107) 2531107..2531574 - 468 WP_000153344.1 SRPBCC domain-containing protein -
K1X69_RS12745 (2531760) 2531760..2533310 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
K1X69_RS12750 (2533499) 2533499..2533570 - 72 Protein_2473 hypothetical protein -
K1X69_RS12755 (2533605) 2533605..2533871 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
K1X69_RS12760 (2533871) 2533871..2534122 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1X69_RS12765 (2534287) 2534287..2534388 - 102 WP_001791744.1 hypothetical protein -
K1X69_RS12770 (2534395) 2534395..2534994 - 600 WP_000162813.1 DsbA family protein -
K1X69_RS12775 (2535013) 2535013..2535372 - 360 WP_000819847.1 DUF4467 domain-containing protein -
K1X69_RS12780 (2535627) 2535627..2536877 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
K1X69_RS12785 (2536974) 2536974..2537705 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
K1X69_RS12790 (2537702) 2537702..2538421 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T212872 WP_000113262.1 NZ_CP081354:c2533871-2533605 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T212872 NZ_CP107389:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT212872 WP_000584502.1 NZ_CP081354:c2534122-2533871 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT212872 NZ_CP107389:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References