Detailed information of TA system TA212871

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2268897..2269114
• Replicon: chromosome
• Accession: NZ_CP081354
• Organism: Staphylococcus aureus strain SQL1

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: K1X69_RS11365
• Protein ID: WP_001802298.1
• Coordinates: 2269010..2269114 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2268897..2268952 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X69_RS11345	2265034..2265699	-	666	WP_001024094.1	SDR family oxidoreductase	-
K1X69_RS11350	2265851..2266171	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
K1X69_RS11355	2266173..2267153	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
K1X69_RS11360	2267419..2268510	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2268897..2268952	+	56	-	-	Antitoxin
K1X69_RS11365	2269010..2269114	-	105	WP_001802298.1	hypothetical protein	Toxin
K1X69_RS11370	2269275..2269758	-	484	Protein_2206	recombinase family protein	-
K1X69_RS11375	2269801..2270937	-	1137	WP_000115564.1	SAP domain-containing protein	-
K1X69_RS11380	2271226..2271318	+	93	WP_001790138.1	hypothetical protein	-
K1X69_RS14675	2271607..2271791	+	185	Protein_2209	exotoxin	-
K1X69_RS11385	2272023..2272880	-	858	WP_000370924.1	HAD family hydrolase	-
K1X69_RS11390	2272948..2273730	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T212871 WP_001802298.1 NZ_CP081354:c2269114-2269010 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T212871 NZ_CP107388:1962-2276 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT212871 NZ_CP081354:2268897-2268952 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin