Detailed information of TA system TA212865

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2094229..2094528
• Replicon: chromosome
• Accession: NZ_CP081354
• Organism: Staphylococcus aureus strain SQL1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K1X69_RS10375
• Protein ID: WP_011447039.1
• Coordinates: 2094352..2094528 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2094229..2094284 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X69_RS10335	2089560..2089820	+	261	WP_001791826.1	hypothetical protein	-
K1X69_RS10340	2089873..2090223	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K1X69_RS10345	2090908..2091357	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K1X69_RS10350	2091452..2091787	-	336	Protein_2006	SH3 domain-containing protein	-
K1X69_RS10355	2092437..2092928	-	492	WP_000919350.1	staphylokinase	-
K1X69_RS10360	2093119..2093874	-	756	WP_000861038.1	CHAP domain-containing protein	-
K1X69_RS10365	2093886..2094140	-	255	WP_000611512.1	phage holin	-
K1X69_RS10370	2094192..2094299	+	108	WP_001791821.1	hypothetical protein	-
-	2094221..2094360	+	140	NuclAT_0	-	-
-	2094221..2094360	+	140	NuclAT_0	-	-
-	2094221..2094360	+	140	NuclAT_0	-	-
-	2094221..2094360	+	140	NuclAT_0	-	-
-	2094229..2094284	+	56	-	-	Antitoxin
K1X69_RS10375	2094352..2094528	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K1X69_RS10380	2094678..2094974	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
K1X69_RS10385	2095032..2095319	-	288	WP_001040261.1	hypothetical protein	-
K1X69_RS10390	2095366..2095518	-	153	WP_001153681.1	hypothetical protein	-
K1X69_RS10395	2095508..2099293	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	2039263..2145821	106558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T212865 WP_011447039.1 NZ_CP081354:c2094528-2094352 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T212865 NZ_CP107383:c5362547-5362164 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT212865 NZ_CP081354:2094229-2094284 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin