Detailed information of TA system TA212862

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1933299..1933481
• Replicon: chromosome
• Accession: NZ_CP081354
• Organism: Staphylococcus aureus strain SQL1

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: K1X69_RS09385
• Protein ID: WP_001801861.1
• Coordinates: 1933299..1933394 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1933422..1933481 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1X69_RS09345	1928959..1929585	+	627	Protein_1846	hypothetical protein	-
K1X69_RS09350	1929626..1929970	+	345	WP_000627551.1	DUF3969 family protein	-
K1X69_RS09355	1930068..1930619	+	552	WP_000414205.1	hypothetical protein	-
K1X69_RS09360	1930837..1931478	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
K1X69_RS09365	1931592..1931777	-	186	WP_000809857.1	hypothetical protein	-
K1X69_RS09370	1931779..1931955	-	177	WP_000375476.1	hypothetical protein	-
K1X69_RS09375	1931966..1932349	-	384	WP_000070811.1	hypothetical protein	-
K1X69_RS09380	1932953..1933096	-	144	WP_001549059.1	transposase	-
K1X69_RS09385	1933299..1933394	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1933422..1933481	-	60	-	-	Antitoxin
K1X69_RS09390	1933517..1933618	+	102	WP_001791893.1	hypothetical protein	-
K1X69_RS09395	1933596..1933772	-	177	Protein_1856	transposase	-
K1X69_RS09400	1933966..1934343	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1895859..2014232	118373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T212862 WP_001801861.1 NZ_CP081354:1933299-1933394 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T212862 NZ_CP107383:c4779998-4779465 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT212862 NZ_CP081354:c1933481-1933422 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin