Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2484533..2485095 Replicon chromosome
Accession NZ_CP081314
Organism Citrobacter farmeri strain CCRI-24236

Toxin (Protein)


Gene name higB Uniprot ID A0A8H9P083
Locus tag Cf24236_RS11760 Protein ID WP_042319014.1
Coordinates 2484533..2484811 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Cf24236_RS11765 Protein ID WP_195293876.1
Coordinates 2484811..2485095 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cf24236_RS11740 (Cf24236_2339) 2479658..2480089 - 432 WP_125368104.1 peroxiredoxin OsmC -
Cf24236_RS11745 (Cf24236_2340) 2480317..2480460 + 144 WP_042319017.1 stationary-phase-induced ribosome-associated protein -
Cf24236_RS11750 (Cf24236_2341) 2480632..2482329 + 1698 WP_042319016.1 malate dehydrogenase -
Cf24236_RS11755 (Cf24236_2342) 2482638..2484353 + 1716 WP_216525616.1 ABC-F family ATP-binding cassette domain-containing protein -
Cf24236_RS11760 (Cf24236_2343) 2484533..2484811 + 279 WP_042319014.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Cf24236_RS11765 (Cf24236_2344) 2484811..2485095 + 285 WP_195293876.1 HigA family addiction module antitoxin Antitoxin
Cf24236_RS11770 (Cf24236_2345) 2485142..2485744 - 603 WP_200040143.1 inorganic diphosphatase -
Cf24236_RS11775 (Cf24236_2346) 2485872..2486528 - 657 WP_195293874.1 formate dehydrogenase-N subunit gamma -
Cf24236_RS11780 (Cf24236_2347) 2486521..2487405 - 885 WP_196014174.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.13 Da        Isoelectric Point: 8.9570

>T212801 WP_042319014.1 NZ_CP081314:2484533-2484811 [Citrobacter farmeri]
MIMNFRHKGLRDLFLHGKTSGVMAKHVRRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWAISVSGNWRLTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T212801 NZ_CP107363:3377109-3377642 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10427.13 Da        Isoelectric Point: 10.2982

>AT212801 WP_195293876.1 NZ_CP081314:2484811-2485095 [Citrobacter farmeri]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLQQAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp

>AT212801 NZ_CP107363:3376832-3377098 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References