Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1883820..1884322 | Replicon | chromosome |
| Accession | NZ_CP081306 | ||
| Organism | Escherichia coli strain Ec1079 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | K5A55_RS09085 | Protein ID | WP_000767829.1 |
| Coordinates | 1884068..1884322 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | K5A55_RS09080 | Protein ID | WP_001259255.1 |
| Coordinates | 1883820..1884071 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5A55_RS09055 (1878997) | 1878997..1880064 | - | 1068 | WP_000080060.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| K5A55_RS09060 (1880064) | 1880064..1881134 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| K5A55_RS09065 (1881131) | 1881131..1882435 | - | 1305 | WP_001317939.1 | histidinol dehydrogenase | - |
| K5A55_RS09070 (1882441) | 1882441..1883340 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| K5A55_RS09075 (1883486) | 1883486..1883536 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| K5A55_RS09080 (1883820) | 1883820..1884071 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| K5A55_RS09085 (1884068) | 1884068..1884322 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| K5A55_RS09090 (1884405) | 1884405..1885229 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
| K5A55_RS09095 (1885275) | 1885275..1886204 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| K5A55_RS09100 (1886419) | 1886419..1886481 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| K5A55_RS09105 (1886471) | 1886471..1887829 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| K5A55_RS09110 (1888008) | 1888008..1889066 | + | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| K5A55_RS09115 (1889080) | 1889080..1889307 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T212776 WP_000767829.1 NZ_CP081306:1884068-1884322 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T212776 NZ_CP107353:274745-275155 [Klebsiella pneumoniae]
GTGAACAGAACGTATATGCTCGATACCCGTTTCTGCGCGTTCATCCTGCGCGAGCAGCCGGAAGCCGTGCTCGGGTGGCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATTGTGATTTCAGCCATCACATGGGCCGAGCTGTCACAGGCCGCGCGGGAGG
ACAGTCCCGCCACGCAGGCTCTGGCCGATGCGTTCTGCGCCAGTCTCGATGTCGTGCTGCCCTGGGACCGCGCCGCGGTG
GATGCGACCACGGAAATTAAGGCAGCCCTGGCGGCGACCGGGACGCCGCTGGGTCCTAACGACACGGCCATTGCCGGACA
CGCCATTGCCGCCGGTGCCGTGCTGGTGACGAGGAACGGGGGAGAGTTTGAGCGGGTGCCGGGCCTCACACTGCAAGACT
GGGCCGGTTAG
GTGAACAGAACGTATATGCTCGATACCCGTTTCTGCGCGTTCATCCTGCGCGAGCAGCCGGAAGCCGTGCTCGGGTGGCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATTGTGATTTCAGCCATCACATGGGCCGAGCTGTCACAGGCCGCGCGGGAGG
ACAGTCCCGCCACGCAGGCTCTGGCCGATGCGTTCTGCGCCAGTCTCGATGTCGTGCTGCCCTGGGACCGCGCCGCGGTG
GATGCGACCACGGAAATTAAGGCAGCCCTGGCGGCGACCGGGACGCCGCTGGGTCCTAACGACACGGCCATTGCCGGACA
CGCCATTGCCGCCGGTGCCGTGCTGGTGACGAGGAACGGGGGAGAGTTTGAGCGGGTGCCGGGCCTCACACTGCAAGACT
GGGCCGGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT212776 WP_001259255.1 NZ_CP081306:1883820-1884071 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT212776 NZ_CP107353:274518-274748 [Klebsiella pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACTGCATCATCCTGCGTCCCGTCCGCCCGGCCTGGAACTCATTCGCCCTGATGG
GGAAGGCCGGGCCTGAGTTTATGGCGGAGCGTGAAGTTGTTATAAGTGATAACGGGCGGGGTGAACAGTGA
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACTGCATCATCCTGCGTCCCGTCCGCCCGGCCTGGAACTCATTCGCCCTGATGG
GGAAGGCCGGGCCTGAGTTTATGGCGGAGCGTGAAGTTGTTATAAGTGATAACGGGCGGGGTGAACAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|