Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 769707..770400 Replicon chromosome
Accession NZ_CP081306
Organism Escherichia coli strain Ec1079

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag K5A55_RS03755 Protein ID WP_000415585.1
Coordinates 769707..770003 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K5A55_RS03760 Protein ID WP_000650107.1
Coordinates 770005..770400 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5A55_RS24750 (764841) 764841..765320 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
K5A55_RS24755 (765323) 765323..766033 + 711 WP_000834030.1 hypothetical protein -
K5A55_RS03730 (766040) 766040..766372 + 333 WP_000914690.1 DUF2645 family protein -
K5A55_RS03735 (766418) 766418..767767 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
K5A55_RS03740 (767764) 767764..768423 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
K5A55_RS03745 (768575) 768575..768967 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K5A55_RS03750 (769020) 769020..769502 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K5A55_RS03755 (769707) 769707..770003 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
K5A55_RS03760 (770005) 770005..770400 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K5A55_RS03765 (770533) 770533..772140 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
K5A55_RS03770 (772278) 772278..774536 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T212771 WP_000415585.1 NZ_CP081306:769707-770003 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T212771 NZ_CP107353:c36580-36296 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTGCAGGTGCATTTCAA
AAAGAAGCTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAGGACGACATTGTTACCGTCACTGTTATCGGTGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT212771 WP_000650107.1 NZ_CP081306:770005-770400 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT212771 NZ_CP107353:c36818-36570 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACGGCAGCCAGCATTACTGAGCTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTGAATCGTAATGAGCCTGCATTCTACTGCGTGCCACCGGCACTGTATGCCCAGTTGA
TGGAACTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References