Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3472549..3473132 Replicon chromosome
Accession NZ_CP081257
Organism Phaeobacter inhibens strain M636

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K4L01_RS16450 Protein ID WP_260099386.1
Coordinates 3472549..3472830 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K4L01_RS16455 Protein ID WP_260099387.1
Coordinates 3472842..3473132 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4L01_RS16435 (K4L01_16415) 3469934..3470473 + 540 WP_076617977.1 toxin-activating lysine-acyltransferase -
K4L01_RS16440 (K4L01_16420) 3470622..3471173 - 552 WP_260099385.1 SGNH/GDSL hydrolase family protein -
K4L01_RS16445 (K4L01_16425) 3471418..3472386 + 969 Protein_3221 IS5 family transposase -
K4L01_RS16450 (K4L01_16430) 3472549..3472830 + 282 WP_260099386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K4L01_RS16455 (K4L01_16435) 3472842..3473132 + 291 WP_260099387.1 HigA family addiction module antitoxin Antitoxin
K4L01_RS16460 (K4L01_16440) 3473300..3474208 - 909 WP_260099388.1 pentapeptide repeat-containing protein -
K4L01_RS16465 (K4L01_16445) 3474221..3474424 - 204 WP_260099389.1 hypothetical protein -
K4L01_RS16470 (K4L01_16450) 3474715..3475548 - 834 WP_260099390.1 hypothetical protein -
K4L01_RS16475 (K4L01_16455) 3475737..3476579 + 843 WP_260099391.1 MobA/MobL family protein -
K4L01_RS16480 (K4L01_16460) 3476905..3477198 - 294 WP_260099392.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3471984..3472373 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-86)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10242.78 Da        Isoelectric Point: 10.0521

>T212756 WP_260099386.1 NZ_CP081257:3472549-3472830 [Phaeobacter inhibens]
MIRSTKGKLAANAVKGKYGKGFPGDLVKRTRAMLSALDAAVVVEDLRFPPGNHLEELKGDRAGQHSVRINGQWRICFVWT
PNGPADVEIVDYH

Download         Length: 282 bp

>T212756 NZ_CP107346:171895-172338 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10720.51 Da        Isoelectric Point: 4.7672

>AT212756 WP_260099387.1 NZ_CP081257:3472842-3473132 [Phaeobacter inhibens]
MSLLEEPMHPGEVLKELYLDPLDMGAIAFARRLDVPRTRIERLIKGTTGITPDTALRLARVFNTIPAYWVNLQTNFDMAV
AAKEIDVSNIEPLIAA

Download         Length: 291 bp

>AT212756 NZ_CP107346:171668-171898 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References